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Flashcards in CNS Infections Intro Deck (28)
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1

What is encephalitis?

diffuse infection of parenchyma

2

What is meningitis?

inflammation of the subarachnoid space

3

What is the most common type meningitis?

viral

4

What is the most worrisome type of meningitis?

bacterial

5

What is a brain abscess?

focal infection of parenchyma

6

How can an abscess cause meningitis?

if it ruptures

7

What is encephalopathy?

diffuse cerebral disfunction without inflammation due to toxin or metabolic dysfunction

8

Immune cells in CNS

microglia, astrocytes

9

What is spreading in the blood called?

hematogenous dissemination

10

This organism causes meningitis and has a 25% mortality rate

Listeria monocytogenes

11

Complication of abscess after LP and need for imaging

possibility of herniation

12

What might induce herniation when abscess is present?

LP

13

Preferred Abx for empiric Tx of suspected meningitis?

3rd generation cephalosporin + ampicillin

14

What Tx is used to treat inflammation in the subarachnoid space?

dexamethasone

15

What is the function of giving steroids in meningitis?

prevent long-complications

16

Mechanism of action of cephtriaxone and ampicillin

transpeptidation of peptidoglycan

17

Potential neurotoxic side effect of cephtriaxone

seizures

18

Bacterial meningitis:
WBC
Protein
Glucose

WBC: high (leukocytes)
Protein: high
Glucose: low

19

Viral meningitis:
WBC
Protein
Glucose

WBC: slightly elevated (lymphocytes)
Protein: slightly elevated
Glucose: normal

20

Mechanism of gentamicin

ribosome inhibitor, aminoglycoside class

21

What are the big three CSF levels we look at for meningitis?

WBC
Protein
Glucose

22

What symptoms are seen in encephalitis that are not seen in meningitis? **

sensory and motor deficits

23

What is pleocytosis?

white blood cells in the CSF

24

Encephalitis: focal or global?

usually focal

25

Encephalopathy: focal or global?

global

26

What is encephalopathy?

diffuse cerebral dysfunction w/o inflammation usually due to toxin or metabolic dysfunction

27

What are the big three Sx of CNS infections?

fever
headache
altered mental state

28

This term means presence of WBC

pleocytosis