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Flashcards in Somatosensation Deck (13)
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1

What temperatures do cold receptors work under?

5-35˚ C

2

What temperatures do hot receptors work under?

30-45˚ C

3

Nociceptors open to what types of stimuli?

heat > 45˚ C and capsaicin

4

Sensitization of what type of receptors causes hyperalgesia?

nociceptors

5

NSAIDs focus to reduce the release of what type of molecule?

prostaglandins

6

What are TRP proteins?

non-specific cation channels that open to many different forms of stimuli

7

What is an itch?

a perception that isn't present

8

3 types of pain

1. acute nociceptive
2. inflammatory
3. neuropathic

9

Two types of nociceptive pain

-fast, sharp pain
-slow, non-well localized pain (C fibers)

10

Neuropathic pain pathophys

complex reorganization of neural pathways, pain even in absence of stimulus

11

Neuropathic pain: CNS or PNS?

both CNS and PNS

12

What is the cause of referred pain?

breakdown in parallel processing

13

Draw out the gate theory of pain

1˚ afferent breaks into two axonal portions:
-excitatory synapse onto 2˚ afferent
-inhibitory synapse onto inhibitory gate cell
-inhibitory gate cell constitutively inhibits 2˚ afferent
-1˚ afferent stimulation excites 2˚ afferent and inhibits inhibitory gate cell
-opiates increase inhibitory gate cell secretions