Peripheral Neuropathy Case Flashcards Preview

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Flashcards in Peripheral Neuropathy Case Deck (3)
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1

Amytriptyline
Drug class
Mechanism of action
Site of action in pain pathway
Side effects
Drug interaction with warfarin?

-norepinephrine reuptake inhibitors
-unknown/norepinephrine reuptake
-reuptake
-weight gain, constipation, dizziness, headache, blurred vision
-increased risk of bleeding

2

Pregabalin
Drug class
Mechanism of action
Site of action in pain pathway
Side effects
Drug interaction with warfarin?

-gaba aminobutyric acid
-reduce Ca2+ dependent GABA (and other) release
-presynaptic nociceptor
-weight gain, constipation, dizziness, headache, blurred vision
-none

3

Capsaicin
Drug class
Mechanism of action
Site of action in pain pathway
Side effects
Drug interaction with warfarin?

-analgesic
-TRPV1 agonist, depletes substance P
-throughout
-erythema, pain, nausea
-increased bleeding risk