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Flashcards in Headaches Deck (19)
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1

What is the pathophysiology of tension headaches?

compression of the greater occipital nerve

2

Tension headaches: unilateral or bilateral?

bilateral

3

What is the treatment for tension headaches?

analgesics and biofeedback

4

What is the pathophysiology of cluster headaches?

hypothalamic activation of trigeminovascular autonomic system

5

Describe the pain in a cluster headache

severe unilateral pressure in orbital, supraorbital, or temporal region

6

What is the treatment for cluster headaches?

supplemental oxygen and sumatriptan

7

What is the pathophysiology of migraine headaches?

unknown, may be cortical depression

8

What are the symptoms of a migraine headache?

unilateral throbbing pain that may last hours or days

9

If someone who has migraines with aura, what do you absolutely not want to give them?

oral contraceptives

10

What is the first-line treatment of migraines?

triptans

11

What is the chemical abbreviation for serotonin?

5-HT

12

What is serotonin synthesized from?

tryptophan

13

What enzyme metabolizes serotonin?

monoamine oxygenase (MAO)

14

Elevated 5-HT levels may preclude what event?

migraine headache

15

What may cause a migraine headache with relation to serotonin?

vasoconstriction

16

Does 5-HT cause vasoconstriction or dilation?

vasoconstriction

17

Triptans work how?

agonize 5-HT1B and 5-HT1D receptors causing vasoconstriction and decreasing pro-inflammatory nucleopeptide release

18

What are the actions of the 5-HT1B and 5-HT1D receptors?

increase K+ permeability and decrease Ca2+ permeability

19

Where are 5-HT1B and 5-HT1D receptors found?

presynaptic neuron and postsynaptic neuron, decrease release on presynaptic neuron