Flashcards in CNS Neurotransmitter Metabolism Deck (18)
These types of proteins are involved in the docking and fusion of NT
What are the 4 categories of NT?
What are examples of biogenic amines?
What are examples of amino acid NT?
Examples of nucleotide NT?
What are the 3 criteria required for classification as a NT?
What are zinc proteases?
enzymes that use a zinc ion and cut snare proteins, stopping vesicle fusion with membrane
2 common zinc proteases
botulinum toxin (at neuromuscular junction)
tetanus toxin (at inhibitory glycine synapse)
-found in spider venom
-causes vesicle fusion even when Ca2+ not present
What is the difference between synthesis and degradation of ACh?
ACh --> acetate + choline
acetyl-CoA + choline -->ACh + SH--CoA
This drug blocks mAChR activity
This drug blocks nAChR activity
How is glutamate metabolized?
-glutamate is transferred from synaptic cleft into astrocyte
-glutamine transferred into presynaptic neuron
What type of receptor, if overstimulated by glutamate, causes apoptosis?
What are the two inhibitory NT in the CNS?
GABA and glycine
This enzyme is the rate limiting step in the synthesis of biogenic amine?
Homovanillic acid is the metabolite of what NT?