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Flashcards in CNS Neurotransmitter Metabolism Deck (18)
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1

These types of proteins are involved in the docking and fusion of NT

SNARE proteins

2

What are the 4 categories of NT?

-biogenic amines
-amino acids
-nucleotides
-other

3

What are examples of biogenic amines?

-acetylcholine
-epinephrine/norepinephrine
-dopamine
-seratonin
-histamine

4

What are examples of amino acid NT?

-glutamate
-GABA
-glycine etc.

5

Examples of nucleotide NT?

-ATP
-adenosine

6

What are the 3 criteria required for classification as a NT?

-present
-released
-receptors present

7

What are zinc proteases?

enzymes that use a zinc ion and cut snare proteins, stopping vesicle fusion with membrane

8

2 common zinc proteases

botulinum toxin (at neuromuscular junction)
tetanus toxin (at inhibitory glycine synapse)

9

alpha-latrotoxin

-found in spider venom
-causes vesicle fusion even when Ca2+ not present

10

What is the difference between synthesis and degradation of ACh?

ACh --> acetate + choline
acetyl-CoA + choline -->ACh + SH--CoA

11

This drug blocks mAChR activity

atropine

12

This drug blocks nAChR activity

curare

13

How is glutamate metabolized?

-glutamate is transferred from synaptic cleft into astrocyte
-Glu-->Gln
-glutamine transferred into presynaptic neuron
-Gln-->Glu

14

What type of receptor, if overstimulated by glutamate, causes apoptosis?

NMDA receptor

15

What are the two inhibitory NT in the CNS?

GABA and glycine

16

This enzyme is the rate limiting step in the synthesis of biogenic amine?

tyrosine hydroxylase

17

Homovanillic acid is the metabolite of what NT?

dopamine

18

Tyrosine hydroxylase is the rate limiting step of the synthesis of what class of NT?

biogenic amines