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Flashcards in NSAIDs Deck (24)
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1

This NSAID binds platelets irreversibly

aspirin

2

This is the precursor metabolite required for prostaglandin, thromboxane, and prostacyclin synthesis

arachadonic acid

3

Function of prostaglandins

inflammation, vasodialation

4

Function of thromboxanes

increase platelet aggregation

5

Function of prostacyclins

decrease platelet aggregation

6

3 functional uses of NSAIDs

analgesic, antipyretic, anti-inflammatory

7

Which COX enzyme is responsible for normal physiological functions?

COX1

8

Which COX enzyme is inducible in an inflammatory response?

COX2

9

How do NSAIDs act as analgesics?

reduce PGE2 and PGI2 that normally sensitize nociceptors, decreasing threshold for nociceptor stimulation

10

How do NSAIDs act as an antipyretic?

PGE2 crosses BBB to hypothalamus, increase temp
NSAIDs block PG synthesis

11

Prostoglandins and prostocyclins together protect the stomach how?

decreasing H+ pumping
increasing mucosa secretion

12

Why might someone on aspirin be anemic?

GI bleeding

13

DC aspirin how long before surgery and why

1 wk
need new platelets

14

DC non-aspirin NSAIDs how long before surgery and why

2 days
t1/2 dependent

15

Presentation of Reye's syndrome

child with viral illness who took aspirin
liver damage and encephalopathy

16

What is the pathophysiology of aspirin hypersensitivity?

shunting of AA to leukotrienes

17

How do NSAIDs cause metabolic alkalosis?

PG move to respiratory center of medulla, increase respiration rate

18

How does aspirin cause metabolic acidosis?

mitochondria uncoupling, increased lactate

19

Long lasting NSAID

naproxen

20

Celecoxib is selective for

COX2 inhibition

21

Watch out for OD in this non-NSAID

what is acetaminophen?

22

N-acetylcysteine is similar to glutathione and used to treat overdose of this medication that causes free radical formation

acetaminophen

23

Do not drink EtOH and take...

acetaminophen

24

Indomethacin is the treatment for

PDA