Flashcards in Drugs affecting Hypothalamic, Pituitary, and Thyroid Function Deck (24):
Prolactin rises during pregnancy, remains elevated until birth, falls afterwards unless the mother breastfeeds/
What does hyper-prolactinemia cause?
Galactorrhea, amenorhea, infertility --> in women
Poor libido, impotence, infertility---> men
Treatment of a prolactinoma
surgery, radiation, Dope Receptor Agonist
What is Cabergoline?
A high Affinity Dopa Receptor Agonist....used in treating hyperprolactinemia
Growth Hormone release is
pulsatile...makes measuring it meaningless
GH release is stimulated by what kind of blood sugar level?
Hypoglycemia...you grow when you're sleeping and when you're sleeping you're fasting.
Hyperglycemia and GH
Hyperglycemia inhibits it
Test for GH deficiency by injecting insulin and measuring GH response
What are the 5 viable options for measuring GH
1) measure GH in pooled blood samples taken over 24 hour periods.
2) Measure IGF-1 *****
3) Inject insulin
4) Use standard height charts...not effective
5) Have the pt drink a high fructose soft drink
GH and prenatal birth
GH does not affect prenatal birth
Adult GH deficiency
Obese, low muscle mass, low CO
Adverse Effects of GH tx in kids
HTN, Papilledema, VISUAL DISTURBANCES, HA, LEUKEMIA
AE's of adults GH treatment
increased muscle and bone mass, Low fat, peripheral edema, carpal tunnel, arthralgia/myalgia
GH excess =
gigantism and acromegaly
GH excess treated with
Ocreotide is what
Somatostatin analog, given in TID injections (there is an extended release form that is given in a slow release once a month injection).
FSH and LH
Can be given directly for infertility in anovulatory women, women with hypogonadism, or infertile women that are ovulating.
Only treats infertility in males, not hypogonadism
GnRH agonist for prostate cancer. Increases LH production initially then decreases LH (and thus testosterone) by downregulating receptors
Purified old bitch piss. Contains LH and FSH
Cetrorelix and Ganirelix
GnRH receptor antagonists that delay the LH surge so that ovulation is delayed and ova have time to develop
T4. Higher doses required in kids. Can take weeks to reach new steady state levels. Monitor levels closely
L3. tablets or injectable