Drugs affecting Hypothalamic, Pituitary, and Thyroid Function Flashcards Preview

Endocrinology > Drugs affecting Hypothalamic, Pituitary, and Thyroid Function > Flashcards

Flashcards in Drugs affecting Hypothalamic, Pituitary, and Thyroid Function Deck (24):
1

Prolactin rises during pregnancy, remains elevated until birth, falls afterwards unless the mother breastfeeds/

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2

What does hyper-prolactinemia cause?

Galactorrhea, amenorhea, infertility --> in women
Poor libido, impotence, infertility---> men

3

Treatment of a prolactinoma

surgery, radiation, Dope Receptor Agonist

4

What is Cabergoline?

A high Affinity Dopa Receptor Agonist....used in treating hyperprolactinemia

5

Growth Hormone release is

pulsatile...makes measuring it meaningless

6

GH release is stimulated by what kind of blood sugar level?

Hypoglycemia...you grow when you're sleeping and when you're sleeping you're fasting.

7

Hyperglycemia and GH

Hyperglycemia inhibits it

8

Test for GH deficiency by injecting insulin and measuring GH response

word

9

What are the 5 viable options for measuring GH

1) measure GH in pooled blood samples taken over 24 hour periods.
2) Measure IGF-1 *****
3) Inject insulin
4) Use standard height charts...not effective
5) Have the pt drink a high fructose soft drink

10

GH and prenatal birth

GH does not affect prenatal birth

11

Adult GH deficiency

Obese, low muscle mass, low CO

12

Somatotropin

Generic GH

13

Adverse Effects of GH tx in kids

HTN, Papilledema, VISUAL DISTURBANCES, HA, LEUKEMIA

14

AE's of adults GH treatment

increased muscle and bone mass, Low fat, peripheral edema, carpal tunnel, arthralgia/myalgia

15

GH excess =

gigantism and acromegaly

16

GH excess treated with

Ocreotide

17

Ocreotide is what

Somatostatin analog, given in TID injections (there is an extended release form that is given in a slow release once a month injection).

18

FSH and LH

Can be given directly for infertility in anovulatory women, women with hypogonadism, or infertile women that are ovulating.

Only treats infertility in males, not hypogonadism

19

Gosarelin

GnRH agonist for prostate cancer. Increases LH production initially then decreases LH (and thus testosterone) by downregulating receptors

20

Menotropin

Purified old bitch piss. Contains LH and FSH

21

Cetrorelix and Ganirelix

GnRH receptor antagonists that delay the LH surge so that ovulation is delayed and ova have time to develop

22

Levothyroxine

T4. Higher doses required in kids. Can take weeks to reach new steady state levels. Monitor levels closely

23

Liothyronine

L3. tablets or injectable

24

Look at the Thyroid drugs on the sheet

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