Equine NSAIDs Flashcards
1
Q
Give some risks of NSAIDs
A
Toxicity Colic Protein loss Diarrhoea Ulcers (gastric and oral) Right dorsal colitis Renal papillary necrosis
2
Q
Name the NSAIDs used in horses
A
Phenylbutasone Suxibuzone Flunixin Meloxicam Carprofen Ketoprofen Fibrocoxib
3
Q
Which 2 NSAIDs are COX-2 selective?
A
Fibrocoxib
Meloxicam
4
Q
How long does it take Fibrocoxib to reach maximal efficacy?
A
4-5 days
5
Q
Which NSAID is not broken down and excreted as readily as other NSAIDs?
A
Carprofen
6
Q
How do NSAIDs work?
A
Inhibit COX enzymes which usually cause prostaglandin release (-> inflammation, fever)
2 forms:
-Non-selective (inhibit production of all prostaglandins)
-Newer, more selective inhibitors which only target inflammation-causing COX-2 prostaglandins
