Flashcards in Gastritis Deck (52):
sign of past ulcers in stomach?
are there normally inflammatory cells in the lamina propria of the stomach?
2 ways that stomach protects itself from it's own acid:
bicarbonate mucous 'gel' layer
5 things that damage stomach mucosal barrier:
What is the role of prostaglandins in stomach mucosal barrier? 4 things
inhibit acid secretion
stim bicarb, mucous
increase blood flow
Acute gastritis lasts how long usually?
a few days
How long does it take for stomach to heal? why?
24-48 hours due to constant regeneration
does H pylori heal spontaneously after progressing to chronic?
Shock or sepsis can do what to stomach?
neutrophils with erosion?
not much bro.
Chronic superficial gastritis bacterial infections you see more what?
All people in ICU are put on what?
proton pump inhibitors
When does an erosion become an ulcer?
once it goes below the muscularis mucosae
defining feature of chronic ulcer?
fibrosis in the deep layers
acute Ulcers in proximal duodenum from what?
acute Ulcers in gastric and duodenum from what? called what?
intracranial injury. Cushing ulcers.
proximal duodenal ulcers are called what?
if you get subactue gastric ulcer with erosion of artery, what clinical manifestation do you see?
What are the 3 main types of chronic gastritis?
What happens in Autoimmune gastritis?
destruction of acid secreting tubules of parietal cells
No parietal cells also mean no intrinsic factor which means?
decreased B12 absorption and defiency
What is spared in autoimmune gastritis?
antrum of stomach
no parietal cells>hypergastriaemia>linear/nodular hyperplasia> increased risk of?
How else can B12 be interfered with in autoimmune gastritis?
IF-Ab secretion complexes with B12 preventing absorption
What are ECL cells?
Chemical chronic gastritis caused by?
reflux of bile/alkaline
long term aspirin/NSAIDS
What happens to mucosa in Chemical chronic gastritis?
disruption of mucus layer
what does epithelial desquamation mean in Chemical chronic gastritis?
foveolar hyperplasia with elongation of gastric pits
vasodilation and oedema
erosions and ulcers in Chemical chronic gastritis?
H. pylori is linked to 2 things:
where do H. pylori find their niche?
below the mucus bicarb gel layer of stomach
Why are H. pylori good at surviving in stomach?
Acute H. pylori infections bring what kind of immune response?
acute inflam (IL-8)
What happens to parietal cells after Acute H. pylori infection?
transient hypochlorhydria up to 4 months
What do antibodies do with Acute H. pylori infection?
helps but not curative
high infection of Acute H. pylori infection means what 2 things?
low rate of clearance
persists for life when established
H.Pylori in intercellular junctions?
yes when it's bad
H.Pylori for cancer sequence
in gastric cancer, there are no more specialized cells in walls of stomach, they are replaced by
lyphoid follicles with germinal centres
in antrum predominant H.Pylori gastritis what happens to acid and results?
chronic inflam, polymorphs
H. Pylori colonisation
in pan-gastritis predominant H.Pylori gastritis what happens to acid and results?
chronic inflam, intestinal metaplasia>adenocarcinoma
What is MALT?
mucosa associated lymphoid tissue
When do you get B-cell lymphoma of MALT?
in H. Pylori chronic pangastritis
92% of duodenal ulcer is caused by?
25% of gastric ulcer is caused by?
where is the most common site of peptic ulcer?
D1 and antrum
3 other common places for peptic ulcers?
1. oesophagus at squamocolumnar junction
2. gastroenterostomy stoma
3. Meckel's diverticulum if H-pylori infected
4 layers of chornic peptic ulcer floor?
1. fibrin exudate
2. narrow zone of fibrinoid necrosis
3. granulation tissue
4. fibrosis: endarteritis/hypertrophied nerves
4 complications of peptic ulcers
penetration (into adjacent organ)
stenosis (pyloric canal and obstruction)
what happens to the muscosal folds with gastric carcinoma?
diffuse-type gastric carcinoma (linitis plastica) looks like?
stomach is sharply punched out, no glands for cells and is discohesive.