Flashcards in Selective Toxicity Deck (23):
Differences between human and bacterial cells:
why is trimethoprim better than sulfonamide?
Trimethoprim is less toxic to mitochondria, first line for UTIs
Cancer drugs target structures or behaviours?
Methotrexate inhibits what?
Methotrexate resembles what?
Is methothrexate selective?
Not really, vaguely
Methotrexate is used for cancer and what else?
what inhibits human dihydrofolate reductase?
Is methotrexate good for a fetus?
Nope. Teratogenic, used to terminate ectopic pregs
What does 1/5th does of cancer strength methotrexate do?
Why don't ducks get cold feet?
they do but don't care, coutercurrent exchange
Why is the arterial vasculature of the testes squiggly?
enhances countercurrent to keep it cool and high testosterone environment (kind of autocrine)
Renal architecture uses countercurrent exchange, what does that mean?
O2 in the artery passes right to the surrounding veins leaving it in relative hypoxia
2 reasons why kidneys are so sensitive to O2 changes?
1. uses countercurrent exchange so it's in relative hypoxia
2. uses ALOT of ATP for transportation of ions etc.
What is the last resort for a kidney when renal blood flow is compromised?
What is a 'triple-whammy' for kidneys?
diuretic, ACE/AT1 receptor antagonist, PLUS an NSAID = acute renal failure
Gentamicin can cause toxicity for kidneys and what else?
ears (ototoxicity), due to attacking hair cells in the cochlea which don't grow back.
Gentamicin ototoxicity is reversible?
What does paraquat do?
herbicidal, destroy cell membranes, proteins, DNA
How is paraquat activated?
photosynthesis/e- transport chain
Is paraquat systemic?