Selective Toxicity Flashcards Preview

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Flashcards in Selective Toxicity Deck (23):
1

Differences between human and bacterial cells:

ribosomes
membrane
cell wall
enzyme
DNA

2

Sulfanilamide resembles:

folic acid

3

why is trimethoprim better than sulfonamide?

Trimethoprim is less toxic to mitochondria, first line for UTIs

4

Cancer drugs target structures or behaviours?

behaviours

5

Methotrexate inhibits what?

purine synthesis

6

Methotrexate resembles what?

Folic acid

7

Is methothrexate selective?

Not really, vaguely

8

Methotrexate is used for cancer and what else?

immuno suppressants

9

what inhibits human dihydrofolate reductase?

methotrexate

10

Is methotrexate good for a fetus?

Nope. Teratogenic, used to terminate ectopic pregs

11

What does 1/5th does of cancer strength methotrexate do?

kills lymphocytes

12

Why don't ducks get cold feet?

they do but don't care, coutercurrent exchange

13

Why is the arterial vasculature of the testes squiggly?

enhances countercurrent to keep it cool and high testosterone environment (kind of autocrine)

14

Renal architecture uses countercurrent exchange, what does that mean?

O2 in the artery passes right to the surrounding veins leaving it in relative hypoxia

15

2 reasons why kidneys are so sensitive to O2 changes?

1. uses countercurrent exchange so it's in relative hypoxia
2. uses ALOT of ATP for transportation of ions etc.

16

What is the last resort for a kidney when renal blood flow is compromised?

prostaglandin-mediated vasodilation

17

What is a 'triple-whammy' for kidneys?

diuretic, ACE/AT1 receptor antagonist, PLUS an NSAID = acute renal failure

18

Gentamicin can cause toxicity for kidneys and what else?

ears (ototoxicity), due to attacking hair cells in the cochlea which don't grow back.

19

Gentamicin ototoxicity is reversible?

Nope.

20

What does paraquat do?

herbicidal, destroy cell membranes, proteins, DNA

21

How is paraquat activated?

photosynthesis/e- transport chain

22

Is paraquat systemic?

Nope. Selective

23

paraquat in humans accumulates where in low doses?

lungs