Hepatitis 1 Flashcards Preview

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Flashcards in Hepatitis 1 Deck (46):
1

how long does acute viral hepatitis last?

weeks to months

2

how long does chronic viral hepatitis last?

years to lifetime

3

what is fulminant disease hepatitis?

sudden severe acute liver failure

4

features of viral hepatitis?

jaundice, dark urine, pale faeces, flu-like

5

does virus cause hepatocyte damage?

nope, usually immune response

6

can hepiatitis cause cancer?

yes

7

what is cirrhosis?

scarring from chronic liver damage

8

Which hepatitises are infectious?

A and E

9

Which hepatitises are 'serum'?

B,D and C

10

are hepatitis viruses cytolytic?

no

11

what happens if you are exposed to hep early in life? 2 things

less severe acute disease
higher rates of chronic infection

12

are hepatitis viruses related to each other? do you get cross protection?

no
no cross protection

13

Which hepiatitises are acute?

A and E

14

Which hepiatitises are chronic?

B,C,D

15

where does Hep A replicate first?

in intestinal epithelia

16

can Hep A survive stomach?

yes

17

Hep A is enveloped? dsRNA? + or -

non-enveloped (+)ssRNA virus

18

where does Hep A replicate second?

liver

19

How does Hep A transmit mainly?

food/water contamination

20

How is HBV and HCV mainly transmitted?

IV drug/sexual

21

increased ALT liver enzyme indicates what?

presence or replicating virus

22

acute infection Hepatitis levels for IgG and IgM?

high for IgM
low for IgG

23

chronic infection Hepatitis levels for IgG and IgM?

low for IgM
high for IgG

24

Hep A IgM ELISA is good or bad for dx?

good
sensitivity >90%
Specificity >99%

25

are nucleic acid tests for hep A better or worse for ELISA?

inferior to ELISA

26

Hep A incubation period?

15-50 days
average 30 days

27

do kids <6 get symptoms for Hep A?

<10%

28

how long do hep A symptoms last?

2-3 weeks

29

how long do you have to give HAV post-exposure immune globulin?

14 days

30

treatment for Hep A?

supportive rehydration and nutrition

31

Hep A virus vaccine is cheap or expensive?

expensive

32

Hep A virus vaccine how created?

grown in culture
inactivated whole firus with formalin
>95% effective after 1 dose

33

Hep E is enveloped? tough? fragile?

non enveloped/fragile

34

what is Caliciviridae?

Hep E

35

Hep E outbreaks usually cause of?

contaminated water

36

person-to-peron transmission in Hep E?

minimal

37

Hep E incubation?

2-10 weeks
40 days average

38

Hep E fatalities?

low overall
preg: 15-25%

39

Hep E vaccine?

nope.

40

100% of adult Hep E get?

jaundice

41

what is a feature in 50% of Hep E cases?

cholestasis

42

Hep E affects which cells? 3 things

intestinal muscosa
Kupffer cells
Hepatocytes

43

Hep E secreted?

in faeces

44

Hep E diagnosis best way? for who usually?

ELISA assay for travelers and outbreaks

45

can you use immune serum globulin for Hep E?

NOPE.

46

treatment for Hep E?

supportive therapy