Flashcards in Hepatitis 1 Deck (46):
how long does acute viral hepatitis last?
weeks to months
how long does chronic viral hepatitis last?
years to lifetime
what is fulminant disease hepatitis?
sudden severe acute liver failure
features of viral hepatitis?
jaundice, dark urine, pale faeces, flu-like
does virus cause hepatocyte damage?
nope, usually immune response
can hepiatitis cause cancer?
what is cirrhosis?
scarring from chronic liver damage
Which hepatitises are infectious?
A and E
Which hepatitises are 'serum'?
B,D and C
are hepatitis viruses cytolytic?
what happens if you are exposed to hep early in life? 2 things
less severe acute disease
higher rates of chronic infection
are hepatitis viruses related to each other? do you get cross protection?
no cross protection
Which hepiatitises are acute?
A and E
Which hepiatitises are chronic?
where does Hep A replicate first?
in intestinal epithelia
can Hep A survive stomach?
Hep A is enveloped? dsRNA? + or -
non-enveloped (+)ssRNA virus
where does Hep A replicate second?
How does Hep A transmit mainly?
How is HBV and HCV mainly transmitted?
increased ALT liver enzyme indicates what?
presence or replicating virus
acute infection Hepatitis levels for IgG and IgM?
high for IgM
low for IgG
chronic infection Hepatitis levels for IgG and IgM?
low for IgM
high for IgG
Hep A IgM ELISA is good or bad for dx?
are nucleic acid tests for hep A better or worse for ELISA?
inferior to ELISA
Hep A incubation period?
average 30 days
do kids <6 get symptoms for Hep A?
how long do hep A symptoms last?
how long do you have to give HAV post-exposure immune globulin?
treatment for Hep A?
supportive rehydration and nutrition
Hep A virus vaccine is cheap or expensive?
Hep A virus vaccine how created?
grown in culture
inactivated whole firus with formalin
>95% effective after 1 dose
Hep E is enveloped? tough? fragile?
what is Caliciviridae?
Hep E outbreaks usually cause of?
person-to-peron transmission in Hep E?
Hep E incubation?
40 days average
Hep E fatalities?
Hep E vaccine?
100% of adult Hep E get?
what is a feature in 50% of Hep E cases?
Hep E affects which cells? 3 things
Hep E secreted?
Hep E diagnosis best way? for who usually?
ELISA assay for travelers and outbreaks
can you use immune serum globulin for Hep E?