Flashcards in GI Immunopathology Deck (20):
5 cardinal signs of inflammation in latin please:
interleukin-1 is an enzyme?
Bacteria work best at which temperatures usually?
36 degrees or lower
what happens if you inject 300ng/kg of interleukin-1 alpha or beta?
mimics septic shock symptoms
how do you activate interleukin-1 alpha or beta?
must be cleaved by interleukin converting enzyme (ICE) at 116
what is Familial cold urticaria?
rare disease, acute inflam to cold. mutation to cryopyrin (ie. NOD-like receptor)
IL-1 converting enzyme is now called what?
what is needed to induce pro IL-1?
what is an inflammasome?
group of proteins focused on converting pro IL-1 into it's active form
in Gout, what is good at activating inflammasomes?
what is Anakinra?
IL-1 receptor antagonist
contraindication for Anakinra?
infections and inflammasomes, describe
many signals, toxins, PAMPS, etc. can activate inflammasomes
One way a salmonella bacterium hidden in macrophages get cleared out?
inflammasomes in cells that are activated usually die and the bacteria get exposed
what is the inflammatory form of cell death called?
salmonella in dendritic cell, how does it recruit CD8+ cells?
releases IL-18>CD8+>IFN-y = intracellular pathogen clearance
8 features of metabolic syndrome
Non-alcoholic fatty liver
Polysystic ovarian syndrome
HHDL (DeCent NaP)
How do you get liver disease from metabolic syndrome?
from insulin resistance due to atherosclerosis activating chronic IL-1