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Flashcards in GI Immunopathology Deck (20):
1

5 cardinal signs of inflammation in latin please:

calor (heat)
dolor (pain)
rubor (red)
tumor (swelling)
functio laesa

2

interleukin-1 is an enzyme?

nope. Protein

3

Bacteria work best at which temperatures usually?

36 degrees or lower

4

what happens if you inject 300ng/kg of interleukin-1 alpha or beta?

mimics septic shock symptoms

5

how do you activate interleukin-1 alpha or beta?

must be cleaved by interleukin converting enzyme (ICE) at 116

6

what is Familial cold urticaria?

rare disease, acute inflam to cold. mutation to cryopyrin (ie. NOD-like receptor)

7

IL-1 converting enzyme is now called what?

Caspase-1

8

what is needed to induce pro IL-1?

TLR activation

9

what is an inflammasome?

group of proteins focused on converting pro IL-1 into it's active form

10

in Gout, what is good at activating inflammasomes?

monosodium-urate crystals

11

what is Anakinra?

IL-1 receptor antagonist

12

Anakinra use?

gout symptoms
rheumatoid arthritis
OA
DMII(?)

13

contraindication for Anakinra?

neutropenia

14

infections and inflammasomes, describe

many signals, toxins, PAMPS, etc. can activate inflammasomes

15

One way a salmonella bacterium hidden in macrophages get cleared out?

inflammasomes in cells that are activated usually die and the bacteria get exposed

16

what is the inflammatory form of cell death called?

pyroptosis

17

salmonella in dendritic cell, how does it recruit CD8+ cells?

releases IL-18>CD8+>IFN-y = intracellular pathogen clearance

18

8 features of metabolic syndrome

Heart Disease
Hypertension
DMII
Lipid problems

Dementia
Cancer
Non-alcoholic fatty liver
Polysystic ovarian syndrome

HHDL DCNP
HHDL (DeCent NaP)

19

How do you get liver disease from metabolic syndrome?

from insulin resistance due to atherosclerosis activating chronic IL-1

20

main sequence in metabolic syndrome?

fat into tissues, precipitates>forms crystals>inflammasomes>IL-1>insulin resistance>hapatocyte damage>liver cancer and diabetes