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Jason's GI Block > GI Immunopathology > Flashcards

Flashcards in GI Immunopathology Deck (20)
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1
Q

5 cardinal signs of inflammation in latin please:

A
calor (heat)
dolor (pain)
rubor (red)
tumor (swelling)
functio laesa
2
Q

interleukin-1 is an enzyme?

A

nope. Protein

3
Q

Bacteria work best at which temperatures usually?

A

36 degrees or lower

4
Q

what happens if you inject 300ng/kg of interleukin-1 alpha or beta?

A

mimics septic shock symptoms

5
Q

how do you activate interleukin-1 alpha or beta?

A

must be cleaved by interleukin converting enzyme (ICE) at 116

6
Q

what is Familial cold urticaria?

A

rare disease, acute inflam to cold. mutation to cryopyrin (ie. NOD-like receptor)

7
Q

IL-1 converting enzyme is now called what?

A

Caspase-1

8
Q

what is needed to induce pro IL-1?

A

TLR activation

9
Q

what is an inflammasome?

A

group of proteins focused on converting pro IL-1 into it’s active form

10
Q

in Gout, what is good at activating inflammasomes?

A

monosodium-urate crystals

11
Q

what is Anakinra?

A

IL-1 receptor antagonist

12
Q

Anakinra use?

A

gout symptoms
rheumatoid arthritis
OA
DMII(?)

13
Q

contraindication for Anakinra?

A

neutropenia

14
Q

infections and inflammasomes, describe

A

many signals, toxins, PAMPS, etc. can activate inflammasomes

15
Q

One way a salmonella bacterium hidden in macrophages get cleared out?

A

inflammasomes in cells that are activated usually die and the bacteria get exposed

16
Q

what is the inflammatory form of cell death called?

A

pyroptosis

17
Q

salmonella in dendritic cell, how does it recruit CD8+ cells?

A

releases IL-18>CD8+>IFN-y = intracellular pathogen clearance

18
Q

8 features of metabolic syndrome

A

Heart Disease
Hypertension
DMII
Lipid problems

Dementia
Cancer
Non-alcoholic fatty liver
Polysystic ovarian syndrome

HHDL DCNP
HHDL (DeCent NaP)

19
Q

How do you get liver disease from metabolic syndrome?

A

from insulin resistance due to atherosclerosis activating chronic IL-1

20
Q

main sequence in metabolic syndrome?

A

fat into tissues, precipitates>forms crystals>inflammasomes>IL-1>insulin resistance>hapatocyte damage>liver cancer and diabetes