Flashcards in GI--Pharmacology Deck (22):
H2 blockers moa, use?
cimetidine and the other -tidines. reversible block of H2 receptors-->decrease H secretion by parietal cells; used in peptic ulcers/gastritis/mild reflux
potent inhibitor of cyp450, antiandrogenic effects (prolactin relase, gynecomastia, impotence, decreased libido); can cross BBB and cause confusion/dizziness/headaches
H2 blockers that decrease renal excretion of creatinine?
cimetidine and ranitidine
proton pump inhibitors? moa? use?
-prazoles; irreversible inhibit H/K ATPase in stomach parietal cells; used in PUD/gastritis/reflux/zollinger ellison
increased risk of C diff infection/PNA, hip fractures, decreased serum Mg2+ after prolonged use
Bismuth, sulcrafate moa?
binds to ulcer base, provides physical protection and allows HCO3 secretion to re-establish pH gradient in mucous layer; use in ulcer healing and traveler's diarrhea
PGE1 analog; increased production and secretion of gastric mucous barrier; decrease acid production;
how to prevent NSAID induced peptic ulcers?
NSAID PUD, maintaining PDA, used to induce labor
abortifacient, cannot use during pregnancy
long acting somatostatin analog used in acute variceal bleeds, acromegaly, VIPoma, and carcinoid tumors
antacid use can cause:
affect absorption, bioavilability, urinary excretion of other drugs by altering gastric and urinary pH or by delaying emptying; all can cause HYPOkalemia
aluminum hydroxide tox?
constipation, hypophosphatemia, proximal muscle weakness, osteodystrophy, seizures
calcium carbinate tox?
hypercalcemia, rebound acid increase
magnesium hydroxide tox?
diarrhea, hyporeflexia, hypotension, cardiac arrest
infliximab moa? uses?
monoclonal antibody to TNF-alpha; used in crohns, UC, RA, ankylosing spondylitis, psoriasis
check before infliximab use?
TB; increased risk of infection including reactivation of latent TB
combination of sulfapyridine (antibiotic) and 5-ASA (anti-inflammatory); activated by colonic bacteria; used in IBD
sulfonamide tox, reversible oligospermia
5-HT3 antagonist-->deceases vagal stimulation; powerful central acting anti-emetic
D2 receptor antagonist; increases resting tone/contractility/LES tone, motility; Does NOT influence colon transport time