GI--Pharmacology Flashcards Preview

USMLE Step 1 > GI--Pharmacology > Flashcards

Flashcards in GI--Pharmacology Deck (22):
1

H2 blockers moa, use?

cimetidine and the other -tidines. reversible block of H2 receptors-->decrease H secretion by parietal cells; used in peptic ulcers/gastritis/mild reflux

2

Cimetidine tox?

potent inhibitor of cyp450, antiandrogenic effects (prolactin relase, gynecomastia, impotence, decreased libido); can cross BBB and cause confusion/dizziness/headaches

3

H2 blockers that decrease renal excretion of creatinine?

cimetidine and ranitidine

4

proton pump inhibitors? moa? use?

-prazoles; irreversible inhibit H/K ATPase in stomach parietal cells; used in PUD/gastritis/reflux/zollinger ellison

5

PPI tox?

increased risk of C diff infection/PNA, hip fractures, decreased serum Mg2+ after prolonged use

6

Bismuth, sulcrafate moa?

binds to ulcer base, provides physical protection and allows HCO3 secretion to re-establish pH gradient in mucous layer; use in ulcer healing and traveler's diarrhea

7

misoprostol

PGE1 analog; increased production and secretion of gastric mucous barrier; decrease acid production;

8

how to prevent NSAID induced peptic ulcers?

give misoprostol

9

misoprostol uses?

NSAID PUD, maintaining PDA, used to induce labor

10

misoprostol contraindication?

abortifacient, cannot use during pregnancy

11

octreotide moa?

long acting somatostatin analog used in acute variceal bleeds, acromegaly, VIPoma, and carcinoid tumors

12

antacid use can cause:

affect absorption, bioavilability, urinary excretion of other drugs by altering gastric and urinary pH or by delaying emptying; all can cause HYPOkalemia

13

aluminum hydroxide tox?

constipation, hypophosphatemia, proximal muscle weakness, osteodystrophy, seizures

14

calcium carbinate tox?

hypercalcemia, rebound acid increase

15

magnesium hydroxide tox?

diarrhea, hyporeflexia, hypotension, cardiac arrest

16

infliximab moa? uses?

monoclonal antibody to TNF-alpha; used in crohns, UC, RA, ankylosing spondylitis, psoriasis

17

check before infliximab use?

TB; increased risk of infection including reactivation of latent TB

18

Sulfsalazine moa?

combination of sulfapyridine (antibiotic) and 5-ASA (anti-inflammatory); activated by colonic bacteria; used in IBD

19

sulfsalazine tox?

sulfonamide tox, reversible oligospermia

20

ondansetron moa?

5-HT3 antagonist-->deceases vagal stimulation; powerful central acting anti-emetic

21

metoclopramide moa?

D2 receptor antagonist; increases resting tone/contractility/LES tone, motility; Does NOT influence colon transport time

22

metoclopramide tox?

increased parkinsonian effects, interacts with digoxin and diabetic agents; contraindicated in patients with SBO or parkinson disease