Immunology--Pharmacology Flashcards Preview

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Flashcards in Immunology--Pharmacology Deck (31):
1

cyclosporine moa

calcineurin inhibitor (calcineurin dephosphorylates NFAT allowing it to translocate to nucleus and activate transcription); binds cyclophilin and blocks T cell activation by preventing IL2 transcription

2

cyclosporine toxicity

nephrotoxic, HTN, HLD, hyperglycemia, tremor, hirsutism, gingival hyperplasia

3

cyclosporine uses besides transplants

psoriasis, rheumatoid arthritis

4

tacrolimus moa

calcineurin inhibtor, binds FK506 binding protein (FKBP), blocks T cell activation by preventing IL-2 transcription

5

tacrolimus toxicity

nephrotoxic, increased risk of diabetes and neurotoxicity; unlike cyclosporine: no gingival hyperplasia or hirsutism

6

sirolimus (rapamycin) moa

binds FKBP and inhibits mTOR, blocks T cell activation and B cell differentiation by preventing IL2 signal transduction;

7

sirolimus tox?

anemia, thrombocytopenia, leukopenia, insulin resistance, hyperlipidemia, NOT nephrotoxic

8

sirolimus is synergistic with..?

cyclosporine

9

Basiliximab moa, tox?

monoclonal ab blocks IL-2R; edema, hypertension, tremor

10

azathioprine moa

antimetabolite precursor of 6-MP, inhibits lymphocyte proliferation by blocking nucleotide synthesis

11

azathioprine tox?

leukopenia, anemia, thrombocytopenia

12

do not combine azathioprine with..?

allopurinol; 6MP degraded by xanthine oxidase;

13

azathioprine is also used for..?

RA, crohns, glomerulonephritis, other autoimmune stuff

14

glucocorticoids moa?

inhibit NFkappaB, suppress both B and T cell function by decreasing transcription of many cytokines

15

glucocorticoid tox?

hyperglycemia, osteoporosis, central obesity, muscle breakdown, psychsis, acne, HTN, cataracts, peptic ulcers; iatrogenic cushings

16

which two immunosuppressants are used specifically for kidney transplant?

sirolimus and basiliximab

17

thrombocytopenia

thrombopoietin and IL-11

18

IL-2

renal cell carcinoma, metastatic melanoma

19

IFN-alpha

hepB/C, kaposi, hairy cell leukemia, condyloma acuminatum, renal cell carcinoma, malignant melanoma

20

IFN-B

multiple sclerosis

21

IFN-gamma

chronic granulomatous disease

22

alemtuzumab

CD52, CLL

23

bevacizumab

VEGF, colorectal cancer, renal cell carcinoma

24

cetuximab

EGFR, stage 4 colorectal cancer; head and neck cancer

25

rituximab

CD20, B cell non hodgkin lymphoma, rheumatoid arthritis, ITP

26

trastuzumab

her2/neu; breast cancer and gastric cancer

27

infliximab, adalimumab

TNF-alpha; IBD, RA, ankylosing spondylitis, psoriasis

28

Natalizumab

a4integrin, MS, Crohns--a4integrin is used in leukocyte adhesion, risk of PML in patients w/ JC virus

29

denosumab

RANKL--OPG mimic; inhibits osteoclast maturation, osteoporosis

30

omalizumab

IgE; allergic asthma

31

palivisumab

RSV F protein; RSV prophylaxis for infants