Flashcards in Immunology--Pharmacology Deck (31):
calcineurin inhibitor (calcineurin dephosphorylates NFAT allowing it to translocate to nucleus and activate transcription); binds cyclophilin and blocks T cell activation by preventing IL2 transcription
nephrotoxic, HTN, HLD, hyperglycemia, tremor, hirsutism, gingival hyperplasia
cyclosporine uses besides transplants
psoriasis, rheumatoid arthritis
calcineurin inhibtor, binds FK506 binding protein (FKBP), blocks T cell activation by preventing IL-2 transcription
nephrotoxic, increased risk of diabetes and neurotoxicity; unlike cyclosporine: no gingival hyperplasia or hirsutism
sirolimus (rapamycin) moa
binds FKBP and inhibits mTOR, blocks T cell activation and B cell differentiation by preventing IL2 signal transduction;
anemia, thrombocytopenia, leukopenia, insulin resistance, hyperlipidemia, NOT nephrotoxic
sirolimus is synergistic with..?
Basiliximab moa, tox?
monoclonal ab blocks IL-2R; edema, hypertension, tremor
antimetabolite precursor of 6-MP, inhibits lymphocyte proliferation by blocking nucleotide synthesis
leukopenia, anemia, thrombocytopenia
do not combine azathioprine with..?
allopurinol; 6MP degraded by xanthine oxidase;
azathioprine is also used for..?
RA, crohns, glomerulonephritis, other autoimmune stuff
inhibit NFkappaB, suppress both B and T cell function by decreasing transcription of many cytokines
hyperglycemia, osteoporosis, central obesity, muscle breakdown, psychsis, acne, HTN, cataracts, peptic ulcers; iatrogenic cushings
which two immunosuppressants are used specifically for kidney transplant?
sirolimus and basiliximab
thrombopoietin and IL-11
renal cell carcinoma, metastatic melanoma
hepB/C, kaposi, hairy cell leukemia, condyloma acuminatum, renal cell carcinoma, malignant melanoma
chronic granulomatous disease
VEGF, colorectal cancer, renal cell carcinoma
EGFR, stage 4 colorectal cancer; head and neck cancer
CD20, B cell non hodgkin lymphoma, rheumatoid arthritis, ITP
her2/neu; breast cancer and gastric cancer
TNF-alpha; IBD, RA, ankylosing spondylitis, psoriasis
a4integrin, MS, Crohns--a4integrin is used in leukocyte adhesion, risk of PML in patients w/ JC virus
RANKL--OPG mimic; inhibits osteoclast maturation, osteoporosis
IgE; allergic asthma