Pharmacology--Toxicities Flashcards Preview

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Flashcards in Pharmacology--Toxicities Deck (70):
1

Antidote: acetaminophen

N-AC (replenishes glutathione)

2

Antidote: AChE inhibitors, organophosphates

Atropine followed by pralidoxime

3

Antidote: amphetamines (basic)

NH4Cl (acidify urine)

4

Antidote: antimuscarinic, anticholinergic agents

physostigmine salicylate, control hyperthermia

5

Antidote: benzodiazepines

flumazenil

6

Antidote: b blocker

glucagon

7

Antidote: carbon monoxide

100 % Oxygen, hyperbaric O2

8

Antidote: Cu, As, Au

Penicillamine

9

Antidote: cyanide

nitrite + thiosulfate, hydroxocobalamin (forms stable cyanocobalamin)

10

Antidote: digitalis

Anti Dig Fab fragments

11

Antidote: heparin

protamine sulfate

12

Antidote: iron

Deferoxamine, deferasirox

13

Antidote: lead

EDTA, dimercaprol, succimer, penicillamine

14

Antidote: mercury, arsenic, gold

Dimercaprol (BAL), succimer

15

Antidote: methylene glycol, ethylene glycol

Fomepezole > ethanol or dialysis

16

Antidote: methemoglobin

methyline blue, vitC

17

Antidote: opioids

naloxone

18

Antidote: salicylates

NaHCO3 (alkalinize urine), dialysis

19

Antidote: TCAs

NaHCO3 (plasma alkalinization)

20

Antidote: tPA, streptokinase, urokinase

Aminocaproic acid

21

Antidote: warfarin

VitK, plasma (fastest reversal for active bleeding)

22

Coronary vasopasm

cocaine, sumatriptan, ergot alkaloids

23

cutaneous flushing

VANC: vancomycin, adenosine, Niacin, Ca2+ channel blockers

24

dilated cardiomyopathy

danorubicin, doxirubicin

25

Torsades de points

Class 3 antiarrhythmics (sotalol) and class IA (quinidine); macrolid antibiotics, antipsychotics, TCAs

26

adrenocortical insufficiency

HPA suppression 2nd to glucocorticoid withdrawal

27

hot flashes

tamoxifen, clomiphene

28

hyperglycemia

tacrolimus, protease inhibitors, niacin, HCTZ, B blockers, corticosteroids (taking pills necessitates having blood checked)

29

hypothyroidism

lithium, amiodarone, sulfonamides

30

acute cholestatic hepatitis, jaundice

erythromycin

31

diarrhea

Might Excite Colon On Accident: metformin, erythromycin, colchicine, orlistat, acarbose

32

Focal to massive hepatic necrosis

liver HAVAc: halothane, amanita phalloides (mushroom), valproic acid, acetaminophen

33

hepatitis

INH

34

pancreatitis

Drugs Causing A Violent Abdominal Distress: didanosine, corticosteroids, alcohol, valproic acid, azathioprine, diuretics (furosemide, HCTZ)

35

agranulocytosis

Drugs CCCrush Myeloblasts and Promyelocytes: Dapsone, clozapine, carbamezepine, colchicine, methimazole, PTU

36

aplastic anemia

Cant Make New Blood Cells Properly: carbamazepine, methimazole, NSAIDs, Benzene, chloramphenicol, PTU

37

direct coombs+ hemolytic anemia

methydopa, penicillin

38

gray baby syndrome

chloramphenicol

39

hemolysis in G6PD deficiency

hemolysis IS D PAIN: INH, sulfonamides, dapsone, primaquine, aspirin, ibuprofen, nitrofurantoin

40

Megaloblastic anemia

have a blast with PMS: phenytoin, methotrexate, sulfa drugs

41

thrombocytopenia

heparin, cimetidine

42

thrombotic complications

OCPs (estrogens)

43

fat redistribution

Fat PiG: protease inhibitors, glucocorticoids

44

gingival hyperplasia

phenytoin, verapamil, cyclosporine, nifedipine

45

hyperuricemia (gout)

Painful Tophi and Feet Need Care; pyrazinamide, thiazides, furosemide, niacin, cyclosporine

46

myopathy

fibrates, niacin, colchicine, hydroxychloroquine, IFN alpha, penicillamine, statins, glucocorticoids

47

Osteoporosis

corticosteroids, heparin

48

Photosensitivity

sulfonamides, amiodarone, tetracyclines, 5 FU (SAT For Photo)

49

Stevens Johnson's syndrome

Steven Johnson has epileptic Allergy to Sulfa drugs and Penicillin: anti epileptic drugs (carbamazepine, ethosuximide, lamotrigine, phenytoin, phenobarbital), allopurinol, sulfa drugs, penicillin

50

SLE like syndrome

lupus is "SHIPP-E": sulfa drugs, hydralazine, INH, procainamide, phenytoin, etanercept

51

teeth discoloration

tetracyclines

52

tendonitis, tendon rupture, cartilage damage

tetracyclines esp in elderly

53

cinchonism

quinidine, quinine

54

parkinson-like snydrome

cogwheel rigidity of ARM: antipsychotics, reserpine, metoclopramide

55

seizures

I BITE My tongue: INH (B6 deficiency), buproprion, imipenem/cilastatin, tramadol, enflurane, metoclopramide

56

tardive dyskinesia

antipsychotics, metoclopramide

57

diabetes insipidus

lithium, demclocycline

58

fanconi syndrome

Expired tetracycline

59

hemorrhagic cystitis

cyclophosphamide, ifosfamide (prevent with mesna)

60

intersitial nephritis

methicillin, NSAIDs, furosemide

61

SIADH

Can't Concentrate Serum Sodium: carbamazepine, cyclophosphamide, SSRIs

62

Dry cough

ACE inhibitors

63

Pulmonary fibrosis

Breathing Air Badly from Meds: bleomycin, amiodarone, busulfan, methotrexate

64

Antimuscarinic

atropine, TCAs, H1 blockers, antipsychotics

65

Disulfiram like reaction

metronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st gen sulfonyureas

66

nephrotoxicity/ototoxicity

aminoglycosides, vancomycin, loop diuretics, cisplatin

67

P450 inducers

Chronic alcoholic Mona steals Phen-Phen and Never REfuses Greasy Carbs: chronic alcohol, modafinil, St Johns wort, Phenytoin, phenobarbital, nevirapine, rifampin, griseofulvin, carbamazepine

68

P450 substrates

Always (X4) think when starting others: anti epileptics, antidepressants, antipsychotics, anesthetics, theophylline, warfarin, statins, OCPs

69

P450 inhibitors

A cute Gentleman "Cipped" Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon Rolls: Acute alcohol abuse, gemfibrozil, ciprofloxacin, INH, grapefruit juice, quinidine, amiodarone, ketoconazole, macolides, sulfonamides, cimetidine, ritonavir

70

Sulfa drugs:

probenecid, furosemide, acetazolamide, celecoxib, thiazides, sulfonamide anbx, sulfsalazine, sulfonylureas (Popular FACTSSS)