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1

shuttles

Glycerol-3-P
Malate

2

Glycerol-3-P
1 NADH will produce ? ATP

1.5

3

Malate
1 NADH will produce ? ATP

2.5

4

G-3-P
produces how many ATP total?

30

5

Malate produces how many ATP total?

32

6

enzymes of the investment phase

hexokinase
phosphoglucose isomerase
phosphofructosekinase
aldolase
triose phosphate isomerase

7

molecules produced during investment phase

d-glucose---start
1.glucose 6-phosphate
2.fructose 6-phosphate
3.fructose 1,6-biphosphate
4.glyceraldehyde 3-phosphate

dihydroxyacetone phosphate

8

what happens to the fructose 1,3-biphosphate?

it goes through an aldol cleavage producing glyceraldehyde 3-phosphate
dihydroxyacetone phosphate

9

what enzymes accompany the ATP investments?

hexokinase
phoshofructokinase

10

what cells have no mitochondria?

RBC

11

What does aerobic glycolysis depend on?

Pa O2
number of mitochondria

12

NADH is

and electron carrier

13

What are the net products of glycolysis?

2 pyruvate
2 NADH
2 ATP

14

Anaerobic glycolysis is dependent on what enzyme?

lactate dehydrogenase

15

Anaerobic glycolysis produces what molecule?

Lactate

16

What are the enzymes of the generation phase?

1. Glyceraldehyde 3-phosphate dehydrogenase
2. phoshoglycerate kinase
3. phoshoglycero-mutase
4. enolase
5. pyruvate kinase

17

glycolysis occurs where

cytosol

18

What is the pace setting enzyme for glycolysis?

phosphofructokinase

19

what inhibits phosphofructokinase

ATP
citrate

20

what is the substrate used by phosphofructokinase?

fructose 6-phosphate

21

vigorously contracting muscles show an increase in what reaction

conversion of pyruvate to lactate

22

If a pt showed very low lactate conversion after working out, what enzyme would be deficient

pyruvate kinase

23

which reactions in glycolysis are irreversable?

the rate limiting reactions

24

what is the oxif=dized product of NADH?

NAD+

25

will a fasting state speed up or slow down glycolysis, why?

a fasting state will slow down glycolysis due to the inhibition of phosphofructokinase. The enzyme is a rate determining enzyme and decreased levels of fructose 2, 6-biphosphate cause inhibition.

26

Fructose 2,6 phosphate is activated by

insulin

27

what are the products of the generation phase of glycolysis?

4 ATP
2 NADH
2 pyruvate

28

what enzyme is reponsible for the phosphorylation of glucose

hexokinase

29

what inhibits hexokinase

glucose 6-phosphate

30

hexokinase has a high affinity for

glucose