micro 2 Flashcards Preview

Anatomy > micro 2 > Flashcards

Flashcards in micro 2 Deck (229)
Loading flashcards...
1

Elie Metchnikoff

1st to observe phagocytes
father of immunology

2

Innate (nonspecific) immunity
Anatomical barriers
mechanical

1.Skin
2.Mucous membranes----saliva/mucus/urine

3

Innate (nonspecific) immunity
Anatomical barriers
chemical

1.skin
2.mucous membranes (Lysozyme and phospholipase A of tears and saliva)

4

Innate (nonspecific) immunity
Anatomical barriers
biological factors

1. skin and mucous membranes (antimicrobial substances, etc)

5

Innate (nonspecific) immunity
Humoral components

1. Complement
2. coagulation system
3. lactoferrin and transferrin
4. lysozyme
5. cytokines

6

neutrophils
kill by

phagocytocis
intracellular killing
(cause inflamation and tissue damage)

7

Innate (nonspecific) immunity
cellular components

1.neutrophils
2.monocytes/microphages
3. NK and LAK cells
4. Eosinophils

8

Humoral components
complement

lysis of bacteria
increase in vascular permeability
recruitment of phagocytic cells

9

Humoral components
coagulation system

increase vascular permeability
recruitment of phagocytes
B-lysin from platelets

10

B-lysin

a cationic detergent

11

Humoral components
lactoferrin and tranferrin

compete with bacteria for iron

12

Humoral components
lysozyme

breaks down bacterial cell wall

13

Humoral components
cytokines

various effects

14

monocytes and microphages
kill by

phagocytosis and intracellular killing
extracellular killing of infected or altered self targets

15

monocytes and microphages
special

antigen presentation for specific immune response

16

NK cells and LAK cells
do what

kill virus infected and altered self targets

17

eosinophils
do what

kill certain parasites

18

Acquired immuity (specific)

react with a specific pathogen, discrete determinates

19

Acquired immuity (specific)
2 kinds

cell-mediated immunity
humoral immunity (Ab)

20

Acquired immuity (specific)
hallmarks

self/non-self discrimination
memory
specificity
diversity

21

Primary lymphoid organs

bone marrow
thymus

FETAL LIVER

22

secondary lymph organs

Spleen
lymph nodes
tonsils
MALT

23

humoral root

fluid contained

24

blood cells

RBC
Platelets
WBC

25

WBCs include

1.monocytes/macrophages
2.Polymorphonuclear granulocytes
neutrophils
eosinophils
basophils
3.Lymphocytes
NK cells
T cells
B cells

26

NK cells are what % of WBC

15

27

Lymphocytes are what % of WBC

20

28

Neutrophils are what % of PMN

95

29

monocyte lysosomes contain

peroxidase
acid hydrolases

30

monocytes become

tissue macrophages