Flashcards in micro 2 Deck (229)
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1
Elie Metchnikoff
1st to observe phagocytes
father of immunology
2
Innate (nonspecific) immunity
Anatomical barriers
mechanical
1.Skin
2.Mucous membranes----saliva/mucus/urine
3
Innate (nonspecific) immunity
Anatomical barriers
chemical
1.skin
2.mucous membranes (Lysozyme and phospholipase A of tears and saliva)
4
Innate (nonspecific) immunity
Anatomical barriers
biological factors
1. skin and mucous membranes (antimicrobial substances, etc)
5
Innate (nonspecific) immunity
Humoral components
1. Complement
2. coagulation system
3. lactoferrin and transferrin
4. lysozyme
5. cytokines
6
neutrophils
kill by
phagocytocis
intracellular killing
(cause inflamation and tissue damage)
7
Innate (nonspecific) immunity
cellular components
1.neutrophils
2.monocytes/microphages
3. NK and LAK cells
4. Eosinophils
8
Humoral components
complement
lysis of bacteria
increase in vascular permeability
recruitment of phagocytic cells
9
Humoral components
coagulation system
increase vascular permeability
recruitment of phagocytes
B-lysin from platelets
10
B-lysin
a cationic detergent
11
Humoral components
lactoferrin and tranferrin
compete with bacteria for iron
12
Humoral components
lysozyme
breaks down bacterial cell wall
13
Humoral components
cytokines
various effects
14
monocytes and microphages
kill by
phagocytosis and intracellular killing
extracellular killing of infected or altered self targets
15
monocytes and microphages
special
antigen presentation for specific immune response
16
NK cells and LAK cells
do what
kill virus infected and altered self targets
17
eosinophils
do what
kill certain parasites
18
Acquired immuity (specific)
react with a specific pathogen, discrete determinates
19
Acquired immuity (specific)
2 kinds
cell-mediated immunity
humoral immunity (Ab)
20
Acquired immuity (specific)
hallmarks
self/non-self discrimination
memory
specificity
diversity
21
Primary lymphoid organs
bone marrow
thymus
FETAL LIVER
22
secondary lymph organs
Spleen
lymph nodes
tonsils
MALT
23
humoral root
fluid contained
24
blood cells
RBC
Platelets
WBC
25
WBCs include
1.monocytes/macrophages
2.Polymorphonuclear granulocytes
neutrophils
eosinophils
basophils
3.Lymphocytes
NK cells
T cells
B cells
26
NK cells are what % of WBC
15
27
Lymphocytes are what % of WBC
20
28
Neutrophils are what % of PMN
95
29
monocyte lysosomes contain
peroxidase
acid hydrolases
30
