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Flashcards in Hypothalamic & Pituitary Hormones Deck (63):
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Growth hormone (GH)

Somatropin

1

Somatropin

Growth hormone (GH)

2

Somatropin
Mechanism of action

Recombinant forms of human GH - acts through GH receptors to increase production of IGF-1

3

Recombinant forms of human GH - acts through GH receptors to increase production of IGF-1

Somatropin
Mechanism of action

4

Somatropin
Effects

Restores normal growth and metabolic GH effects in GH-deficient individuals.
Increases final adult height in some children with short stature not due to GH deficiency

5

Restores normal growth and metabolic GH effects in GH-deficient individuals.
Increases final adult height in some children with short stature not due to GH deficiency

Somatropin
Effects

6

Somatropin
Clinical application

Replacement in GH deficiency.
Increased final adult height in children with certain conditions associated with short stature.
Wasting in HIV infection.
Short bowel syndrome

7

Replacement in GH deficiency.
Increased final adult height in children with certain conditions associated with short stature.
Wasting in HIV infection.
Short bowel syndrome

Somatropin
Clinical application

8

Somatropin
Toxicity

Pseudotumor cerebri
Slipped capital femoral epiphysis
Edema
Hyperglycemiaj
Progression of scoliosis
Sleep apnea

9

Pseudotumor cerebri
Slipped capital femoral epiphysis
Edema
Hyperglycemiaj
Progression of scoliosis
Sleep apnea

Somatropin
Toxicity

10

Somatostatin analogs

Octreotide
Lanreotide

11

Lanreotide

Somatostatin analog

12

Octreotide

Somatostatin analog

13

Octreotide
Mechanism of action

Agonist at somatostatin receptors

14

Agonist at somatostatin receptors

Octreotide
Mechanism of action

15

Octreotide
Effects

Inhibits production of GH and, to a lesser extent, of TSH, glucagon, insulin, and gastrin

16

Inhibits production of GH and, to a lesser extent, of TSH, glucagon, insulin, and gastrin

Octreotide
Effects

17

Octreotide
Clinical applications

Acromegaly and several other hormone-secreting tumors
Acute control of bleeding from esophageal varices

18

Acromegaly and several other hormone-secreting tumors
Acute control of bleeding from esophageal varices

Octreotide
Clinical applications

19

Octreotide
Toxicity

Gastrointestinal disturbance
Gallstones
Bradycardia
Cardiac conduction problems

20

Gastrointestinal disturbance
Gallstones
Bradycardia
Cardiac conduction problems

Octreotide
Toxicity

21

GH receptor antagonist

Pegvisomant

22

Pegvisomant

GH receptor antagonist

23

Pegvisomant
Mechanism of action

Blocks GH receptors

24

Blocks GH receptors

Pegvisomant
Mechanism of action

25

Pegvisomant
Effects

Ameliorates effects of excess GH production

26

Ameliorates effects of excess GH production

Pegvisomant
Effects

27

Pegvisomant
Clinical applications

Acromegaly

28

Acromegaly

Pegvisomant
Clinical applications

29

Pegvisomant
Toxicity

Increased liver enzymes

30

Increased liver enzymes

Pegvisomant
Toxicity

31

Gonadotropins: Follicle-stimulating hormone (FSH) analogs

Follitropin alpa
Follitropin beta
Urofollitropin
Menotropins

32

Follitropin alpa

Gonadotropin: Follicle-stimulating hormone (FSH) analog

33

Follitropin beta

Gonadotropin: Follicle-stimulating hormone (FSH) analog

A recombiant product with the same peptide sequence as follitropin alfa but differs in carbohydrate side chains

34

Urofollitropin

Gonadotropin: Follicle-stimulating hormone (FSH) analog

Human FSH purified from urine of postmenopausal women

35

Menotropins

Gonadotropin: Follicle-stimulating hormone (FSH) analog

(hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity

36

Gonadotropin: Follicle-stimulating hormone (FSH) analog

A recombiant product with the same peptide sequence as follitropin alfa but differs in carbohydrate side chains

Follitropin beta

37

Gonadotropin: Follicle-stimulating hormone (FSH) analog

Human FSH purified from urine of postmenopausal women

Urofollitropin

38

Gonadotropin: Follicle-stimulating hormone (FSH) analog

(hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity

Menotropins

39

Follitropin alpa
Mechanism of action

Activates FSH receptors

40

Activates FSH receptors

Follitropin alpa
Mechanism of action

41

Follitropin alpa
Effects

Mimics effects of endogenous FSH

42

Mimics effects of endogenous FSH

Follitropin alpa
Effects

43

Follitropin alpa
Clinical applications

Controlled ovulation hyperstimulation in women
Infertility due to hypogonadotropic hypogonadism in men

44

Controlled ovulation hyperstimulation in women
Infertility due to hypogonadotropic hypogonadism in men

Follitropin alpa
Clinical applications

45

Follitropin alpa
Toxicity

Ovarian hyperstimulation syndrome and multiple pregnancies in women
Gynecomastia in men
Headache, Depression, Edema in both sexes

46

Ovarian hyperstimulation syndrome and multiple pregnancies in women
Gynecomastia in men
Headache, Depression, Edema in both sexes

Follitropin alpa
Toxicity

47

Gonadotropins:Luteinzing hormone (LH) analogs

Human chorionic gonadotropin (hCG)
Choriogonadotropin alpa
Lutropin
Menotropins (hMG)

48

Human chorionic gonadotropin (hCG)

Gonadotropin:Luteinzing hormone (LH) analog

49

Choriogonadotropin alpa

Gonadotropin:Luteinzing hormone (LH) analog

Recombiant form of hCG

50

Lutropin

Gonadotropin:Luteinzing hormone (LH) analog

Recombinant form of human LH

51

Menotropins (hMG)

Gonadotropin:Luteinzing hormone (LH) analog

(hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity

52

Gonadotropin:Luteinzing hormone (LH) analog

Recombiant form of hCG

Choriogonadotropin alpa

53

Gonadotropin:Luteinzing hormone (LH) analog

Recombinant form of human LH

Lutropin

54

Gonadotropin:Luteinzing hormone (LH) analog

(hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity

Menotropins (hMG)

55

Human chorionic gonadotropin (hCG)
Mechanism of action

Agonist at LH receptor

56

Agonist at LH receptor

Human chorionic gonadotropin (hCG)
Mechanism of action

57

Human chorionic gonadotropin (hCG)
Effects

Mimics effects of endogenous LH

58

Mimics effects of endogenous LH

Human chorionic gonadotropin (hCG)
Effects

59

Human chorionic gonadotropin (hCG)
Clinical applications

Initiation of ovulation during controlled ovulation hyperstimulation
Ovarian follicle development in women with hypogonadotropic hypogonadism
Male hypogonadotropic hypogonadism

60

Initiation of ovulation during controlled ovulation hyperstimulation
Ovarian follicle development in women with hypogonadotropic hypogonadism
Male hypogonadotropic hypogonadism

Human chorionic gonadotropin (hCG)
Clinical applications

61

Human chorionic gonadotropin (hCG)
Toxicity

Ovarian hyperstimulation syndrom and multiple pregnancies in women
Gynecomastia in men
Headache, depression, edema in both sexes

62

Ovarian hyperstimulation syndrom and multiple pregnancies in women
Gynecomastia in men
Headache, depression, edema in both sexes

Human chorionic gonadotropin (hCG)
Toxicity