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Flashcards in Immunology Deck (51):
1

Encapsulated organisms

(Please SHINE my SKiS)
Pseudomonas aeurginosa, s. pneumo, h. flu, n. meningitidis, e. coli, salmonella, klebsiella pneumo, GBS`

2

From where does the thymus develop?

3rd and 4th pharyngeal pouches

3

Disease associated with HLA A3

Hemochromatosis

4

Dz assoc. w/ HLA B8

Addison, myasthenia gravis

5

Dz assoc. w/ DQ2/8

Celiac (I ate too much gluten at Dairy Queen)

6

Dz assoc. w/ DR2

MS, hay fever, SLE, Goodpasture

7

Dz assoc. w/ DR3

T1DM, SLE, Graves, Hashimoto, Addison

8

Dz assoc. w/ DR4

RA (4 walls in a room), T1DM, Addison

9

Dz assoc. w/ DR5

Pernicious anemia, Hashimoto

10

NK activity enhanced by these cytokines

IL-2, 12, IFN alpha, beta

11

Contraindication in hereditary angioedema

ACE inhibitors.
HA is a C1 esterase inhibitor deficiency. Leads to unregulated conversion of kallikrein to bradykinin. ACE inhibitors block degradationof bradykinin, making it worse

12

IL-1 (secreting cell, and the effects)

Macrophages
Osteoclast-activating factor
Fever, acute inflammation, activates endothelium
("Hot T-bone stEAK")

13

IL-2 (secreting cell, and the effects)

Secreted by all T cells
Stimulates all T cell types, and NK cells
("Hot T-bone stEAK")

14

IL-3 (secreting cell, and the effects)

Secreted by all T cells. Supports growth and differentiation of bone
("Hot T-bone stEAK")

15

IFN-gamma (secreting cell, and the effects)

Secreted by NK cells and T cells in response to IL-12 from macrophaghes
Stimulates macrophages to kill phagocytozed pathogens
Also activates NK cells and increases antigen presentation by all cells
Inhibits Th2 differentiation

16

IL-4 (secreting cells, and the effects)

Secreted by Th2 cells
Induces Th2 differentiation and class switches to IgE and G
("Hot T-bone stEAK")

17

IL-5 (secreting cells, and the effects)

Secreted by Th2 cells
Enhances class switching to IgA and stimulates eosinophils
("Hot T-bone stEAK")

18

IL-10 (secreting cells, and the effects)

Secreted by Th2 cells and Tregs
Attenuates response

19

IL-6 (secreting cells, and the effects)

Secreted by macrophages
Fever and acute phase proteins
("Hot T-bone stEAK", K is for akute)

20

IL-8 (secreting cells, and the effects)

Secreted by macrophages
Major chemotactic factor for neutrophils
("clean up on isle 8")

21

IL-12 (secreting cells, and the effects)

Secreted by macrophages
Induces Th1 differentiation and activates NK cells

22

TNF-alpha (secreting cells and the effects)

Secreted by macrophages
Septic shock, activates endothelium, recruits WBCs, vascular leak
Also causes cachexia in malignancy

23

Exposure to these pathogens can be treated by passive immunity

Tetanus, botilinum, HBV, varicella, rabies
("to be healed very rapidly")

24

This is the only live attenuated vaccine given to people with HIV

MMR

25

Inactivated vaccines

Rabies, influenza (injection), Polio (salk), hepatitis A
("RIP Always")

26

Dz assoc. w/ anticentromere ab

limited scleroderma (CREST)

27

Dz assoc. w/ anti-desmoglein

aka anti-desmosome. Pemphigus vulgaris

28

Dz assoc. w/ anti-dsDNA, anti-Sm

SLE

29

Dz assoc. w/ anti-hemidesmosome

bullous pemphigoid

30

Dz assoc. w/ anti-histone

drug induced lupus

31

Dz assoc. w/ anti-Jo-1, anti-SRP, anti-Mi-2

polymyositis, dermatomyositis

32

Dz assoc. w/ anti-microsomal

hashimoto. also assoc w/ antithyroglobulin

33

Dz assoc. w/ anti-mitochondrial ab

primary biliary cirrhosis

34

Dz assoc. w/ anti-phospholipase A2 receptor

primary membranous nephropathy

35

Dz assoc. w/ anti-Scl-70 (anti-topoisomerase II)

diffuse scleroderma

36

Dz assoc. w/ anti-smooth muscle

Autoimmune hepatitis type I

37

Dz assoc w/ anti-Ro, anti-La (aka SSA, SSB)

sjogren syndrome

38

Dz assoc. w/ anti-U1 RNP

MCTD

39

Dz assoc w/ P-ANCA (MPO-ANCA)

microscopic polyangiitis, Churg-Strauss (eosinophilic granulomatosis with polyangiitis)

40

Dz assoc. w/ C-ANCA (PR3-ANCA)

Wegener's (granulomatosis with polyangiitis)

41

This immunodeficiency has an increased risk of autoimmune disease

CVID

42

Etiology of Job syndrome

Th17 deficiency due to STAT3 mutation

43

Clinical manifestations of Job syndrome

FATED: facies, cold staph abscesses, retained primary teeth, increased IgE, dermatologic problems (eczema)

44

lab findings in ataxia-telangietasia

lymphopenia, low antibody titer, high AFP

45

Catalase positive organisms

Nocardia, pseudomonas, listeria, aspergillus, candida, e. coli, staph, serratia, b cepacia, h pylori
("Cats Need PLACESS to Belch their Hairballs")

46

Abnormal screening test sin GCD

Dihydrorhodamine (flow cytometry) and nitroblue tetrazolium dye reduction (stays clear)

47

AE cyclosporine and tacrolimus

Both nephrotoxicity, HTN, hyperlipidemia, and neurotoxicity.
Cyclosporine uniquely has gingival hyperplasia and hirsutism
Tacrolimus has increased risk of diabetes and neurotoxicity, but none of CsA' unique ones

48

AE of sirolumus (ripamycin)

pancytopenia ("panSirtopenia"), insulin resistance, hyperlipidemia, spares kidney

49

AE of daclizumab, basilixumab

Edema, HTN, tremor

50

Allopurinol increases toxicity of this immunosuppresant

azathioprine

51

AE mycophenolate mofetil

GI upset, pancytopenia, HTN, hyperglycemia. Associated with invasive CMV infection