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Immunology Flashcards

(51 cards)

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1
Q

Encapsulated organisms

A

(Please SHINE my SKiS)

Pseudomonas aeurginosa, s. pneumo, h. flu, n. meningitidis, e. coli, salmonella, klebsiella pneumo, GBS`

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2
Q

From where does the thymus develop?

A

3rd and 4th pharyngeal pouches

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3
Q

Disease associated with HLA A3

A

Hemochromatosis

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4
Q

Dz assoc. w/ HLA B8

A

Addison, myasthenia gravis

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5
Q

Dz assoc. w/ DQ2/8

A

Celiac (I ate too much gluten at Dairy Queen)

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6
Q

Dz assoc. w/ DR2

A

MS, hay fever, SLE, Goodpasture

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7
Q

Dz assoc. w/ DR3

A

T1DM, SLE, Graves, Hashimoto, Addison

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8
Q

Dz assoc. w/ DR4

A

RA (4 walls in a room), T1DM, Addison

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9
Q

Dz assoc. w/ DR5

A

Pernicious anemia, Hashimoto

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10
Q

NK activity enhanced by these cytokines

A

IL-2, 12, IFN alpha, beta

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11
Q

Contraindication in hereditary angioedema

A

ACE inhibitors.
HA is a C1 esterase inhibitor deficiency. Leads to unregulated conversion of kallikrein to bradykinin. ACE inhibitors block degradationof bradykinin, making it worse

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12
Q

IL-1 (secreting cell, and the effects)

A

Macrophages
Osteoclast-activating factor
Fever, acute inflammation, activates endothelium
(“Hot T-bone stEAK”)

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13
Q

IL-2 (secreting cell, and the effects)

A

Secreted by all T cells
Stimulates all T cell types, and NK cells
(“Hot T-bone stEAK”)

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14
Q

IL-3 (secreting cell, and the effects)

A

Secreted by all T cells. Supports growth and differentiation of bone
(“Hot T-bone stEAK”)

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15
Q

IFN-gamma (secreting cell, and the effects)

A

Secreted by NK cells and T cells in response to IL-12 from macrophaghes
Stimulates macrophages to kill phagocytozed pathogens
Also activates NK cells and increases antigen presentation by all cells
Inhibits Th2 differentiation

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16
Q

IL-4 (secreting cells, and the effects)

A

Secreted by Th2 cells
Induces Th2 differentiation and class switches to IgE and G
(“Hot T-bone stEAK”)

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17
Q

IL-5 (secreting cells, and the effects)

A

Secreted by Th2 cells
Enhances class switching to IgA and stimulates eosinophils
(“Hot T-bone stEAK”)

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18
Q

IL-10 (secreting cells, and the effects)

A

Secreted by Th2 cells and Tregs

Attenuates response

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19
Q

IL-6 (secreting cells, and the effects)

A

Secreted by macrophages
Fever and acute phase proteins
(“Hot T-bone stEAK”, K is for akute)

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20
Q

IL-8 (secreting cells, and the effects)

A

Secreted by macrophages
Major chemotactic factor for neutrophils
(“clean up on isle 8”)

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21
Q

IL-12 (secreting cells, and the effects)

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A

Secreted by macrophages

Induces Th1 differentiation and activates NK cells

22
Q

TNF-alpha (secreting cells and the effects)

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A

Secreted by macrophages
Septic shock, activates endothelium, recruits WBCs, vascular leak
Also causes cachexia in malignancy

23
Q

Exposure to these pathogens can be treated by passive immunity

Study These Flashcards
A

Tetanus, botilinum, HBV, varicella, rabies

“to be healed very rapidly”

24
Q

This is the only live attenuated vaccine given to people with HIV

25
Inactivated vaccines
Rabies, influenza (injection), Polio (salk), hepatitis A | "RIP Always"
26
Dz assoc. w/ anticentromere ab
limited scleroderma (CREST)
27
Dz assoc. w/ anti-desmoglein
aka anti-desmosome. Pemphigus vulgaris
28
Dz assoc. w/ anti-dsDNA, anti-Sm
SLE
29
Dz assoc. w/ anti-hemidesmosome
bullous pemphigoid
30
Dz assoc. w/ anti-histone
drug induced lupus
31
Dz assoc. w/ anti-Jo-1, anti-SRP, anti-Mi-2
polymyositis, dermatomyositis
32
Dz assoc. w/ anti-microsomal
hashimoto. also assoc w/ antithyroglobulin
33
Dz assoc. w/ anti-mitochondrial ab
primary biliary cirrhosis
34
Dz assoc. w/ anti-phospholipase A2 receptor
primary membranous nephropathy
35
Dz assoc. w/ anti-Scl-70 (anti-topoisomerase II)
diffuse scleroderma
36
Dz assoc. w/ anti-smooth muscle
Autoimmune hepatitis type I
37
Dz assoc w/ anti-Ro, anti-La (aka SSA, SSB)
sjogren syndrome
38
Dz assoc. w/ anti-U1 RNP
MCTD
39
Dz assoc w/ P-ANCA (MPO-ANCA)
microscopic polyangiitis, Churg-Strauss (eosinophilic granulomatosis with polyangiitis)
40
Dz assoc. w/ C-ANCA (PR3-ANCA)
Wegener's (granulomatosis with polyangiitis)
41
This immunodeficiency has an increased risk of autoimmune disease
CVID
42
Etiology of Job syndrome
Th17 deficiency due to STAT3 mutation
43
Clinical manifestations of Job syndrome
FATED: facies, cold staph abscesses, retained primary teeth, increased IgE, dermatologic problems (eczema)
44
lab findings in ataxia-telangietasia
lymphopenia, low antibody titer, high AFP
45
Catalase positive organisms
Nocardia, pseudomonas, listeria, aspergillus, candida, e. coli, staph, serratia, b cepacia, h pylori ("Cats Need PLACESS to Belch their Hairballs")
46
Abnormal screening test sin GCD
Dihydrorhodamine (flow cytometry) and nitroblue tetrazolium dye reduction (stays clear)
47
AE cyclosporine and tacrolimus
Both nephrotoxicity, HTN, hyperlipidemia, and neurotoxicity. Cyclosporine uniquely has gingival hyperplasia and hirsutism Tacrolimus has increased risk of diabetes and neurotoxicity, but none of CsA' unique ones
48
AE of sirolumus (ripamycin)
pancytopenia ("panSirtopenia"), insulin resistance, hyperlipidemia, spares kidney
49
AE of daclizumab, basilixumab
Edema, HTN, tremor
50
Allopurinol increases toxicity of this immunosuppresant
azathioprine
51
AE mycophenolate mofetil
GI upset, pancytopenia, HTN, hyperglycemia. Associated with invasive CMV infection

First Aid (18 decks)

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