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Flashcards in Musculoskeletal Deck (128):
1

McMurray test

Popping on external rotation is medial meniscal tear

Popping on internal rotation is lateral meniscal tear

2

innervation of rotator cuff

C5-C6

3

innervation supraspinatus

suprascapular nerve

4

innervation infraspinatus

suprascapular nerve

5

innervation of teres minor

axillary nerve

6

innervation of subscapularis

upper and lower subscapular nerves

7

dislocation of which wrist bone can cause acute carpal tunnel

lunate

8

damage of which wrist bone can damage ulnar nerve

hamate

9

which wrist bones are directly distal to scaphoid

trapezium laterally
trapezoid
capitate most medially

10

lunate articulates with which bones

scaphoid, capitate, hamate, triquetrum (contains pisiform)

11

Guyon canal syndrome

compression of ulnar nerve at wrist or hand, seen in cyclists

12

what roots contribute to axillary nerve

C5-C6

13

what roots contribute to radial nerve

C5-T1

14

what roots contribute to musculocutaneous nerve

C5-C7

15

roots of median nerve

C5-T1

16

roots of ulnar nerve

C8-T1

17

lesion in Erb palsy (waiter's tip deformity)

upper trunk

18

lesion causing (total) claw hand (Klumpke palsy)

lower trunk

19

lesion causing wrist drop

posterior cord or radial nerve

20

lesion in saturday night palsy

radial nerve

21

lesion winged scapula

long thoracic nerve

22

lesion difficulty flexing elbow + variable sensory loss

musculocutaneous

23

lesion Ape's hand and Pope's blessing

median nerve

24

lesion 4th and 5th claw

ulnar nerve

25

a distal ulnar nerve lesion causes

ulnar claw when extending

26

a proximal ulnar nerve lesion causes

OK gesture when making a fist

27

a distal median nerve lesion causes

median claw

28

a proximal median nerve lesion causes

Pope's blessing when making a fist

29

thoracic outlet syndrome compresses which part of brachial plexus

lower trunk

30

roots of obturator nerve

L2-L4

31

roots of femoral nerve

L2-L4

32

roots of common peroneal nerve

L4-S2

33

roots of tibial nerve

L4-S3

34

roots of superior gluteal nerve

L5-S2

35

roots of sciatic nerve

L4-S3

36

roots of inferior gluteal nerve

L5-S2

37

roots of pudendal nerve

S2-S4

38

artery paired with long thoracic nerve

lateral thoracic A

39

artery paired with axillary nerve

posterior circumflex A

40

artery paired with radial nerve

deep brachial A

41

artery paired with median nerve in distal humerus

brachial A

42

artery paired with tibial nerve in popliteal fossa

popliteal A

43

artery paired with tibial nerve in leg

posterior tibial A

44

in muscle contraction, calcium binds to

troponin C

45

sarcomere Z line

the ends of each sarcomere, connects one sarcomere to the next

46

sarcomere M line

mid-sarcomere line, through myosin

47

sarcomere A band

myosin band, always stays the same length

48

sarcomere H band

space between actin filaments, overlies myosin, bisected by M line

49

sarcomere I band

actin that is not overlying myosin, bisected by Z line

50

which muscle fibers are slow

type 1 fibers

51

mutation achondroplasia

gof FGFR3, only affects endochondral ossification

52

osteoporosis DEXA score

T score less than -2.5

53

disease that can cause hat size increase and hearing loss

Paget disease of bone

54

lab values osteoporosis

normal

55

lab values osteopetrosis

possibly low calcium

56

lab values Paget disease of bone

high ALP

57

lab values osteofibrosa cystica

consistent with primary hyperthyroidism

high calcium, low phosphate, high ALP, high PTH

58

lab values secondary hyperthyroidism

low calcium, high phosphate, high ALP, high PTH

59

lab values osteomalacia/rickets

low calcium, low phosphate, high ALP, high PTH

60

lab values hypervitaminosis D

high calcium, high phosphate, low PTH

61

MC bone location Ewing

diaphysis

62

MC bone location osteosarcoma

metaphysis

63

MC bone location osteochondroma

metaphysis

64

MC bone location myeloma

diaphysis

65

MC bone location osteoid osteoma

diaphysis, periosteum

66

MC bone location fibrous dysplasia

diaphysis

67

MC bone location simple bone cyst

border of diaphysis and metaphysis

68

MC bone location giant cell tumor

epiphysis. the only tumor here

69

soap bubble sign on this bone tumor

giant cell tumor

70

onion skin periosteal reaction in this bone tumor

Ewing

71

codman triangle or sunburst pattern in this bone tumor

osteosarcoma

72

Li-Fraumeni, Paget disease of bone, and familial retinoblastoma are risk factors for this bone tumor

osteosarcoma

73

anaplastic small blue cells in this bone tumor

Ewing

74

biomodal distribution in this bone tumor

osteosarcoma

75

Bouchard nodes are in

proximal IP

76

birefringence of gout

negative, yellow needles when under parallel light

77

Heberden's nodes are in

distal IP

78

gout composition

monosodium urate

79

pseudogout composition

calcium pyrophosphate

80

heart finding associated with ankylosing spondylitis

aortic regurgitation

81

antibody that represents poor prognosis in SLE

anti-dsDNA means renal disease

82

antibody in MCTD

anti-U1 RNP

83

lupus pernio

skin lesions on face resembling lupus, seen in sarcoid

84

Schaumann bodies

calcium + protein in Langerhans cells. a finding in sarcoid

85

finding on bronchoalveolar lavage in sarcoid

elevated CD4+/CD8+ ratio

86

CK in PMR is [normal/elevated]

normal

87

antibodies polymyositis/dermatitis

anti-Jo-1, anti-SRP, anti-Mi-2

88

antibody diffuse scleroderma

anti-Scl-70

89

antibody limited scleroderma (CREST)

anti-centromere

90

name the skin layers from out to in

corneum, lucidum, granulosum, spinosum, basale

91

what are the proteins in tight junctions

claudins and occludins

92

proteins in adherens junction

cadherins

93

a disease with hypergranulosis

lichen planus

94

a disease with acanthosis

(epidermal hyperplasia, spinosum) acanthosis nigricans
also psoriasis (spinosum gets larger, granulosum shrinks)

95

types of lesions in lesser-trelat

seborrheic keratosis

96

cause of bacillary angiomatosis

bartonella henselae

97

cause of kaposi sarcoma

HHV8

98

disease associated with cystic hygroma

Turner syndrome

99

MCC impetigo

s pyogenes or s aureus

100

MCC bullous impetigo

s aureus

101

MCC erysipelas

s pygones

102

area of skin lysed in staph scaled skin syndrome

stratum granulosum

103

area of skin lysed in TEN

epidermal-dermal junction

104

Wickham striae

reticular white lines in mucosa. seen with lichen planus

105

disease association with lichen planus

HCV

106

disease that has a herald patch followed by scaly erythematous plaques in christmas tree distribution

pityriasis rosea

107

acanthosis, sawtooth dermal-epidermal junction with band of lymphocytic infiltrate seen in

lichen planus

108

skin cancer with palisading nuclei

BCC

109

keratoacanthoma is a variant of which skin cancer

SCC. grows rapidly and can regress

110

4 types of melanoma

superficial, nodular, lentigo maligna, acral lentiginous

111

MOA denosumab

mAb vs. RANKL

112

what part of arachidonic pathway do steroids block

blocks phospholipase A2 and blocks NF-kappa-B (which is a COX2 activator)

113

MOA zileuton

blocks 5-lipoxyganse to prevent leukotriene formation

114

MOA montelukast, zafirlukast

block CysLT1 receptor

note: montelukast is singulair

115

celecoxib MOA

COX-2 blocker only

116

MOA leflunomide

reversibly inhibits dihydroorotate dehydrogenase to prevent pyrimidine syntehsis

117

MOA teriparatide

recombinant PTH, incudes formation in pulsatile administration for osteoporosis treatment

118

AE teriparatide

causes transient hypercalcemia

119

class of drugs: "-dronate"

bisphosphonates

120

MOA and use pegloticase

uricase to metabolize uric acid into allantoin. used for gout

121

why is aspirin not used in gout?

salicylates impair uric acid clearance

122

which drug is like allopurinol

febuxostat

123

class of drugs: adalimumab

TNF-alpha inhibitor similar to infliximab

124

MOA and use rasburicase

uricase simialr to pegloticase, but used to prevent tumor lysis syndrome

125

alprostdil: analog of, and use

PGE1, erectile dysfunction and to maintain PDA

126

misoprostol: analog of, and use

PGE1, prevention of NSAID-induced gastric ulcers, abortifacient

127

Latanoprost: analog of, and use

PGF2-alpha, treatment of chronic glaucoma

128

dinoprostone and carboprost: analogs of, and use

D: PGE2, C: PGF2-alpha
abortifacient, ripening of cervix for induction of labor