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Flashcards in Immunology Deck (209)
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1

Examples of Type III hypersensitivity reactions

Farmers lung Pigeon Fanciers lungSystemic Lupus Erythematosus (SLE)

2

Where do macrophages reside?

Epithelial tissue i.e. lung, skin, gut

3

What happens to the complement proteins when they enter an inflammed tissue?

become activate by enzymatic cleavage thus activating the complement cascade

4

TRUE OR FALSE - phagocytes are particularly important in the defence against viruses and bacteria

FALSE - they are important in the defence against bacteria and fungi

5

microglia

macrophages in the brain

6

Most abundant immunoglobulin

IgG

7

What role do mast cells, basophils and eosinophils have in the immune response?

protect against large pathogens which cannot be phagocytosedalso play a role in mediating allergic reactions

8

Functions of Phagocytes (5)

Initiation and amplification of inflammatory response Scavenging of cellular and infectious debris Ingest and kill micro-organisms Resolution and repair Produce inflammatory molecules regulating immune system

9

IL-4 and IL-13 result in the production of further...

IgE

10

Cytotoxic T cells recognise which MHC class

Class I

11

G-CSF is

granulocyte colony stimulating factor which assist the maturation of neutrophils

12

Type III hypersensitivity reactions are the result of deposition or formation of ______ _____ in situ

immune complexes

13

Examples of Secondary Immune Deficiencies

HIV, Malignancy, nutrition disorder, infection, treatment interventions

14

What does the innate immune system recognise in infectious organisms?

PAMPs

15

where are monocytes found?

circulating the blood - move into peripheral tissues and differentiate into macrophages

16

Proteins of acquired immune response (1)

Antibodies

17

When a B lymphocyte is activated, what happens?

Undergoes complex genetic rearrangement, forms memory cells and plasma cells

18

Cytotoxic T cells are particularly important in defence against?

Viruses and Fungi

19

Describe the IL-12 --> IFNy network

infected macrophages produce IL-12IL-12 induces Th1 cells to secrete IFNyIFNy feeds back to macrophages and neutrophils Leads to production of TNF --> NADPH oxidaseOxidative pathways

20

What level of B cells would you expect in a DiGeorge patient?

Normal or increased B cells

21

Where is the primary lymphoid tissue?

Bone marrow and thymus gland

22

What are the subdivisions of T cells?

Helper T cellsCytotoxic T cells

23

How long does Type IV hypersensitivity take to develop?

24-48 hours

24

Phagocytes of the innate immune system (2)

Macrophagesneutrophils

25

Which cells are highly granular?

mast cells, basophils and eosinophils

26

What does the innate immune system recognise in infectious organisms?

PAMPs

27

What is IL-2 involved in?

ability to respond to other cytokines T cell and NK development production of B cells

28

What are the other cells of the immune system?

mast cells, eosinophils, basophils

29

What level of B cells would you expect in a DiGeorge patient?

Normal or increased B cells

30

What is lymphoedema?

a condition of localised fluid retention and tissue swelling caused by a compromised lymphatic system