Infection 10 - Immunodeficiency Diseases Flashcards Preview

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Flashcards in Infection 10 - Immunodeficiency Diseases Deck (13):
1

What is the underlying cause of a primary immunodeficiency disease?

Genetic defect:
- Missing immunoglobulin
- Missing T or B cell
- Non-functional components of immune system

2

What is a secondary immunodeficiency disease?

An acquired immunodeficiency disease, due to underlying disease/treatment

3

What are the 4 warning signs that suggest an immunodeficiency disease?

1) Severe infections (require hospital treatment)
2) Persistent infections (even with treatment)
3) Unusual infections (site/organism)
4) Recurrent infections

Use SPUR

4

If an individual has an antibody deficiency, what type of infections will they be prone to?

- Viral
- Bacterial
- Protozoan

5

What is the most common type of primary immunodeficiency disease?

Antibody deficiency

6

Name the 3 most common primary antibody deficiency diseases:

1) Common Variable Immunodeficiency (CVID)
2) IgA deficiency
3) Bruton's disease (X-linked agammaglobinaemia)

7

If an individual has combined B + T cell immunodeficiency disease, what type of infections will they be prone to?

- Viral
- Fungal
- Bacterial
- Protozoan

8

Severe Combine Immunodeficiency Disease (SCID) is what type of immunodeficiency disease?

Combined B + T cell deficiency

9

If an individual has a phagocytic defect immunodeficiency disease, what type of infections will they be prone to?

- Bacterial
- Fungal

10

Chronic Granulomatous Disease is what type of immunodeficiency disease?

Phagocytic defect

11

If an individual has a complement deficiency disease, what type of infections will they be prone to?

- Bacterial infections

12

Why do primary antibody deficiency diseases present after 6 months of age?

Maternal IgG lasts until about 6 months of age

13

List some common causes of secondary immunodeficiency diseases:

- Malnutrition
- Infection
- Splenectomy
- Liver disease
- Lymphoproliferative diseases
- Haematological malignancies
- Protein-losing conditions (Nephropathy etc)
- Burns