Infection 5 - Adaptive Immune System Flashcards
(38 cards)
Where are antigen presenting cells located in the body?
- Skin
- Mucous membranes
- Lymphoid organs
- Blood
Where are dendritic cells found in the body?
- Lymph nodes
- Mucous membranes
- Blood
What cells can dendritic cells present antigens to?
- T cells
- B cells
Where are Langerhans’ cells found in the body?
Skin
What cells can Langerhans’ cells present antigens to?
T cells
Where are B cells found in the body?
Lymphoid tissue
Which immune cells can present antigens to B cells?
Dendritic cells
What is another name used for Major Histocompatibility Complexes (MHC molecules)?
Human Leukocyte Antigens (HLA)
Where are Class I MHC molecules found, and what cells do they present peptides to?
- All nucleated cells
- CD8+ T-cells
Which class of MHC molecules present peptides from INTRAcellular microbes to T cells?
Class I
Which class of MHC molecules present peptides from EXTRAcellular microbes to T cells?
Class II
Where are Class II MHC molecules found, and what cells do they present peptides to?
- Dendritic cells, Macrophages, B cells
- CD4+ T-cells
Why is it better to have many, diverse MHC molecules, rather than a select few?
More, diverse MHC molecules mean a wider range of antigens/microbes can be presented to our immune system, protecting us against infectious disease.
How do CD8+ T-cells respond when peptides from intracellular microbes are presented to them?
Directly kill the cell via:
- Perforins
- Granzymes
Where do T cells mature?
Thymus
What does a T-cell Receptor interact with?
- Peptide antigen
- MHC molecule
Which surface glycoproteins are expressed by T helper cells?
CD3+
CD4+
What are the 3 main types of T helper cells?
1) TH1
2) TH2
3) TH17
Which surface glycoproteins are expressed by cytotoxic/cytolytic T cells?
CD3+
CD8+
Are T cells memory cells?
Yes
Which cytokines are produced by CD4+ TH1 cells?
TNF-alpha
IFN-gamma
Which cytokines are produced by CD4+ TH2 cells?
IL-4
IL-5
IL-10
Which cytokine is produced by CD4+ TH17 cells?
IL-17
CD4+ TH1 cells stimulate which cells against intracellular microbes?
- B cells
- Macrophages
- CD8+ Cytotoxic T lymphocytes (CTL)
