Infection 5 - Adaptive Immune System Flashcards Preview

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Flashcards in Infection 5 - Adaptive Immune System Deck (38):
1

Where are antigen presenting cells located in the body?

- Skin
- Mucous membranes
- Lymphoid organs
- Blood

2

Where are dendritic cells found in the body?

- Lymph nodes
- Mucous membranes
- Blood

3

What cells can dendritic cells present antigens to?

- T cells
- B cells

4

Where are Langerhans' cells found in the body?

Skin

5

What cells can Langerhans' cells present antigens to?

T cells

6

Where are B cells found in the body?

Lymphoid tissue

7

Which immune cells can present antigens to B cells?

Dendritic cells

8

What is another name used for Major Histocompatibility Complexes (MHC molecules)?

Human Leukocyte Antigens (HLA)

9

Where are Class I MHC molecules found, and what cells do they present peptides to?

- All nucleated cells
- CD8+ T-cells

10

Which class of MHC molecules present peptides from INTRAcellular microbes to T cells?

Class I

11

Which class of MHC molecules present peptides from EXTRAcellular microbes to T cells?

Class II

12

Where are Class II MHC molecules found, and what cells do they present peptides to?

- Dendritic cells, Macrophages, B cells
- CD4+ T-cells

13

Why is it better to have many, diverse MHC molecules, rather than a select few?

More, diverse MHC molecules mean a wider range of antigens/microbes can be presented to our immune system, protecting us against infectious disease.

14

How do CD8+ T-cells respond when peptides from intracellular microbes are presented to them?

Directly kill the cell via:
- Perforins
- Granzymes

15

Where do T cells mature?

Thymus

16

What does a T-cell Receptor interact with?

- Peptide antigen
- MHC molecule

17

Which surface glycoproteins are expressed by T helper cells?

CD3+
CD4+

18

What are the 3 main types of T helper cells?

1) TH1
2) TH2
3) TH17

19

Which surface glycoproteins are expressed by cytotoxic/cytolytic T cells?

CD3+
CD8+

20

Are T cells memory cells?

Yes

21

Which cytokines are produced by CD4+ TH1 cells?

TNF-alpha
IFN-gamma

22

Which cytokines are produced by CD4+ TH2 cells?

IL-4
IL-5
IL-10

23

Which cytokine is produced by CD4+ TH17 cells?

IL-17

24

CD4+ TH1 cells stimulate which cells against intracellular microbes?

- B cells
- Macrophages
- CD8+ Cytotoxic T lymphocytes (CTL)

25

Which T helper cells help kill intracellular microbes? (stimulate cells to kill microbes)

CD4+ TH1

26

Which T helper cells help kill extracellular microbes? (stimulate cells to kill microbe)

CD4+ TH2
CD4+ TH17

27

CD4+ TH2 cells stimulate which cells against extracellular microbes?

- Mast cells
- B cells
- Eosinophils

28

CD4+ TH17 cells stimulate which cells against extracellular microbes?

- Neutrophils

29

What are the 4 types of antibodies?

1) IgG
2) IgA
3) IgM
4) IgE

30

Which antibody is produced in the primary immune response?

IgM

31

Which antibodies are produced in the secondary immune response?

IgA
IgG

32

Which antibody is the most abundant in the blood?

IgG

33

Which antibody can cross the placenta?

IgG

34

Which antibody offers immunity against helminths?

IgE

35

Which antibody causes allergic reactions?

IgE

36

Which antibodies activate the complement cascade?

IgM
IgG

37

Which antibodies give mucosal immunity to pathogenic invasion?

IgA

38

Which antibody is restricted to the vascular system, and why?

IgM
High molecular weight