Intro to Leukocyte Neoplasm (Part 1) (General Info) Flashcards Preview

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Flashcards in Intro to Leukocyte Neoplasm (Part 1) (General Info) Deck (31)
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1

AML-NOS Minimal Differentiation

M0

2

AML-NOS Without Differentiation

M1

3

AML NOS With Maturation

M2

4

AML With Recurrent Cytogenetic Abnormalities -
Acute promyelocytic Leukemia t(15;17) APL

M3

5

AML-NOS Acute Myelomonocytic Leukemia
AMML

M4

6

AML With Recurrent Cytogenetic Abnormalities
AML With Abnormal Marrow Eosinophils

M4eo

7

AML NOS Acute Monoblastic Leukemia

M5a

8

AML NOS Acute Monocytic Leukemia

M5b

9

AML NOS Acute Erythroleukemia

M6

10

AML NOS Acute Megakaryocytic Leukemia

M7

11

Genes that cause dominant-acting cancer mutations (one copy)

oncogene

12

Codes for a protein found in normal cell cycle regulation. Mutation my form an oncogene and result in disruption of normal cell cycle

proto-oncogene

13

Genes codes for proteins that help cells resist malignant transformation

tumor suppressor gene

14

While oncogenes act in a dominant fashion, tumor suppressor genes transform cells into a malignant phenotype only after _______ _______ have been lost or inactivated. WHAT theory is this?

BOTH alleles
- 2 hit theory (Knudson)

15

Treatment/Therapy: oral or parenteral cancer treatment with compounds that posses anti tumor properties

Chemotherapy

16

Two types of chemotherapy

- Phase Specific
- Phase Nonspecific

17

Treatment/Therapy: use of ionizing energy to kill malignant cells by damaging DNA

Radiation

18

Treatment/Therapy: Involves the use of pharmaceuticals to manage symptoms of malignancies and malignancy treatments including colony stimulating factors and erythropietin

Supportive Therapy

19

Treatment/Therapy: type of medication that blocks growth of cancer cells by interfering with specific target molecules. More effective and less harmful than traditional methods

Targeted Treatment

20

Treatment/Therapy: Replacement of the patient's hematopoietic stem cells

Stem Cell Transplant

21

Two types of stem cell transplants

Allogeneic
Autologous

22

Donor is genetically different than the patient

Stem Cell Transplant: Allogeneic

23

Patient's own stem cells are removed, conditioned, and transplanted back into the patient

Stem Cell Transplant: Autologous

24

ACUTE v.s. CHRONIC
- Age of onset

Acute: all ages
Chronic: adult

25

ACUTE v.s. CHRONIC
- Clinical onset

Acute: sudden
Chronic: slow/insidious

26

ACUTE v.s. CHRONIC
- Course if untreated

Acute: < 6 month survival
Chronic: 2-6 years

27

ACUTE v.s. CHRONIC
- Maturity of cells

Acute: Immature
Chronic: Mature

28

ACUTE v.s. CHRONIC
- Anemia

Acute: Mild to severe
Chronic: mild

29

ACUTE v.s. CHRONIC
- Thrombocytopenia

Acute: Mild to severe
Chronic: Mild

30

ACUTE v.s. CHRONIC
- WBC Count

Acute: Variable
Chronic: Increased