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Hematology Module 2 > Introduction to Bone Marrow > Flashcards

Flashcards in Introduction to Bone Marrow Deck (17)
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0

where is the location of red marrow at birth?

all is mostly red marrow

1

where is red marrow at age 5-7?

yellow marrow beginning to replace red

2

location of red marrow in adults?

red marrow limited to "warm" sites such as the axial skeleton and proximal portions of extremeties

3

Where are BM samples taken from?

Prefer Posterior iliac crest (Hips and long bones) in both children and adults

4

the bone marrow aspirate is the ______ portion of marrow

liquid

5

Which sample do you perform a diff with?

the liquid aspirate

6

What purpose does obtaining a BM biopsy serve?

Estimate cellularity, evaluation of architecture, and allows us to perform immunohistochemical staining

8

Normal Myeloid:Erythroid ratio in adults

1.5:1 to 3.3:1

9

Normocellular formula % of cellularity

% = (100 - age) +/- 10

10

Comprehensive bone marrow examination includes what? (4)

- Peripheral blood smear
- bone marrow aspirates
- bone marrow core biopsy/aspirate colt selection
- ancillary studies

11

Ancillary studies include but not limited to... (6)

- immunohistochemistry
- special stains
- flow cytometry
- cytogenetics
- molecular
- microbiology

12

What does the presence of spicules on a bone marrow aspirate indicate?

indicates that the specimen was correctly collected (aka "adequate")

13

Be able to identify spicules on a bone marrow

?

14

When performing a diff on a bone marrow aspirate, you perform counts and cellular morphology by looking where?

look around the edges of spicule, not against the spicule. Cells may be distorted!

15

Function of osteoblasts

- synthesize bone

16

Function of osteoclasts

- Bone resorption

17

______ should have an even number of lobes that are not separated.

megakaryocytes