Quantitative WBC Abnormalities (Part 1) Flashcards Preview

Hematology Module 2 > Quantitative WBC Abnormalities (Part 1) > Flashcards

Flashcards in Quantitative WBC Abnormalities (Part 1) Deck (53)
Loading flashcards...
0

When do primary granules appear?

Promyelocyte

1

What is the composition of a neutrophils secondary granule?

Leukocyte Alkaline

2

These things describe what cell?
-dawn of neutrophilia (2' Granules)
-flattend side of the nucleus
-perinuclear clearing (Hoff area)

myelocyte

3

Dark blue/purple cytoplasmic granules in metamyelocytes, bands, or neutrophils; primary cause is infection

Toxic Granulation

4

Decreased sideroblasts (RBC precursors with iron) are present in patients with what form of anemia?

ACD

5

________ granules that are peroxidase positive are present in toxic granulation

primary

6

CRP and Toxic granulation are considered a marker of _________

inflammation

7

small oval, pale blue inclusions in the peripheral cytoplasm of bands and segs; pushed to the edge; may be in single or in multiples

Doehle Bodies

8

The DOehle Body is made of ______

RNA

9

Doehle body primary cause.

Infection (can also be burns, trauma, pregnancy, etc)

10

absent or decreased number of granules in neutrophils that can be caused naturally

hypogranulation/agranulation

11

this is caused by fusion of cytoplasmic granules with phagosome (infection); a toxic change

Hypogranulation/Agranulation

12

primary cause linked to chromosomal abnormalities in hypogranulation/agranulation

Myelodysplastic Syndrome (MDS)

13

toxic change in the cytoplasm of neutrophils; primarily caused septicemia and bacterial infections; other important causes include prolonged exposure to EDTA and acute alcoholism

Vacuolization/vacuolation

14

what are the 3 comrades often seen together in infections?

Vacuoles, toxic granulation, and Doehle Bodies

15

red staining rods or bodies found in the cytoplasm of malignant immature myeloid cells; found in Faggot cells; bundle of sticks

Auer Rods

16

Auer rods are composed of fused ________ granules

Primary

17

What is the primary cause of Auer Rods?

Acute myeloid Leukemia (AML)

18

inclusions in neutrophils that are morphologically indistinguishable from Doehle bodies; rare autosomal dominant trait

May-Hegglin Anomaly

19

May-Hegglin Anomaly are composed of _______

RNA

20

these are associated with thrombocytopenia and giant platelets

may-hegglin anomaly

21

prominant azurphilic granules, resembles toxic granulation; the granules are fromed by the accumulation of partially degraded mucopolysaccharides in lysosomes

Alder-Reilly Anomaly

22

Alder-Reilly Anomaly is autosomal _________

recessive

23

lysosomal organelles affected; large azurophilic granules; red granules predominant in LYMPHOCYTES; grey/blue seen in neutrophils; causes impaired chemotaxis and defective granulation and abnormal membranes of abnormal lysosomes

Chediak-Higashi Anomaly

24

Chediak-Higashi Anomaly is rare and autosomal ________

recessive

25

anomaly caused by failure of segmentation of granulocyte nuclei; band form with two lobes, dumbbell, bikini top, peanut

Pelger-Huet Anomaly

26

Pelger-Huet Anomaly is autosomal _________; and >______ of neutrophils are affected

dominant; 80%

27

Is heterozygous or homozygous more common in Pelger-Huet Anomaly?

Heterozygous

28

in acquired Pelger-Huet, when less than 50% of neutrophils are affected the most common disease is ________ ________

myelodysplastic syndromes (MDS)

29

greater than 5 lobes in a poly or > or equal to 6 polys with 5 lobes

Hyperseg