Flashcards in Quantitative WBC Abnormalities (Part 1) Deck (53)
When do primary granules appear?
What is the composition of a neutrophils secondary granule?
These things describe what cell?
-dawn of neutrophilia (2' Granules)
-flattend side of the nucleus
-perinuclear clearing (Hoff area)
Dark blue/purple cytoplasmic granules in metamyelocytes, bands, or neutrophils; primary cause is infection
Decreased sideroblasts (RBC precursors with iron) are present in patients with what form of anemia?
________ granules that are peroxidase positive are present in toxic granulation
CRP and Toxic granulation are considered a marker of _________
small oval, pale blue inclusions in the peripheral cytoplasm of bands and segs; pushed to the edge; may be in single or in multiples
The DOehle Body is made of ______
Doehle body primary cause.
Infection (can also be burns, trauma, pregnancy, etc)
absent or decreased number of granules in neutrophils that can be caused naturally
this is caused by fusion of cytoplasmic granules with phagosome (infection); a toxic change
primary cause linked to chromosomal abnormalities in hypogranulation/agranulation
Myelodysplastic Syndrome (MDS)
toxic change in the cytoplasm of neutrophils; primarily caused septicemia and bacterial infections; other important causes include prolonged exposure to EDTA and acute alcoholism
what are the 3 comrades often seen together in infections?
Vacuoles, toxic granulation, and Doehle Bodies
red staining rods or bodies found in the cytoplasm of malignant immature myeloid cells; found in Faggot cells; bundle of sticks
Auer rods are composed of fused ________ granules
What is the primary cause of Auer Rods?
Acute myeloid Leukemia (AML)
inclusions in neutrophils that are morphologically indistinguishable from Doehle bodies; rare autosomal dominant trait
May-Hegglin Anomaly are composed of _______
these are associated with thrombocytopenia and giant platelets
prominant azurphilic granules, resembles toxic granulation; the granules are fromed by the accumulation of partially degraded mucopolysaccharides in lysosomes
Alder-Reilly Anomaly is autosomal _________
lysosomal organelles affected; large azurophilic granules; red granules predominant in LYMPHOCYTES; grey/blue seen in neutrophils; causes impaired chemotaxis and defective granulation and abnormal membranes of abnormal lysosomes
Chediak-Higashi Anomaly is rare and autosomal ________
anomaly caused by failure of segmentation of granulocyte nuclei; band form with two lobes, dumbbell, bikini top, peanut
Pelger-Huet Anomaly is autosomal _________; and >______ of neutrophils are affected
Is heterozygous or homozygous more common in Pelger-Huet Anomaly?
in acquired Pelger-Huet, when less than 50% of neutrophils are affected the most common disease is ________ ________
myelodysplastic syndromes (MDS)