Flashcards in Leukocyte Development, Kinetics, & Function Deck (64)
A bacterial infection will most likely cause a dramatic increase in which cell line?
3 forms of cell production
Erythropoiesis, Leukopoiesis, and Megakaryopoiesis
2 forms of leukopoiesis
Myelopoiesis and lymphopoiesis
Where does hematopoiesis occur?
this theory suggests that all blood cells are derived from a single progenitor stem cell
Growth factors and ______ are terms that can be used interchangeably
these are a group of soluble proteins that modulate the functional activites of other cells; responsible for stimulation or inhibition of RBC maturation
an essential cytokine in the early stages of hematopoiesis because stimulates cell proliferation
C-Kit; aka Stem Cell Factor
what does GM-csf stand for?
What does Meg-csf stand for?
what does G-csf stand for?
What does M-csf stand for?
How can colony stimulating factors be used in patient care?
To start production of different cell lines
Cytokines that exhibit multiple biologic activities including regulation of autoimmune and infammatory reactions and hematopoiesis
2 examples of interleukins
IL-3 and IL-6
Interleukin that controls production, differentiation, and function of granulocytes and macrophages
Interleukin that stimulates myeloid and lymphoid cell linneages
programmed cell death
accidental cell death
as cell matures what two things happen?
Decrease in cell size and decrease in N:C ratio
What specific changes occur in the nucleus during cell maturation?
loss of nucleoli, decrease in size, condensation of chromatin, possible shape changes, possible nucleus ejections
What specific changes occur in the cytoplasm during cell maturation?
Decrease in basophilia, increase in amount of cytoplasm, and granules may appear
This cell has a nucleus with 2-5 nucleoli, moderate basophilia with less than 5 granules, and is not present in peripheral blood; these cells are increased in leukemia
These cells have a round to oval nucleus with 1-3 or more nucleoli, slightly coarser chromatin than myeloblast, basophilic cytoplasm with few red to purple primary granules and no secondary granules; these are not present in peripheral blood under normal conditions
Primary granules are composed of ________
Secondary granules are composed of _______
These cells have a round to oval nucleus that may have one flattened side, nucleoli not ususally visible, coarse chromatin, and is more condensed that promyelo; the cytoplasm is slightly basophilic but starting to turn pink due to granules; these are not present in peripheral blood under normal conditions
This cell has an indented nucleus, nucleoli are not visible, and chromatin is coarse and clumped; cytoplasm is pink; not found in peripheral blood under normal conditions
this cell has a band shaped nucleus which is constricted but no threadlike filament; cytoplasm is pink; and ______% are found in peripheral blood