Leukocyte Development, Kinetics, & Function Flashcards Preview

Hematology Module 2 > Leukocyte Development, Kinetics, & Function > Flashcards

Flashcards in Leukocyte Development, Kinetics, & Function Deck (64)
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0

A bacterial infection will most likely cause a dramatic increase in which cell line?

Neutrophils

1

3 forms of cell production

Erythropoiesis, Leukopoiesis, and Megakaryopoiesis

2

2 forms of leukopoiesis

Myelopoiesis and lymphopoiesis

3

Where does hematopoiesis occur?

Bone Marrow

4

this theory suggests that all blood cells are derived from a single progenitor stem cell

Monophyletic Theory

5

Growth factors and ______ are terms that can be used interchangeably

cytokines

6

these are a group of soluble proteins that modulate the functional activites of other cells; responsible for stimulation or inhibition of RBC maturation

cytokines

7

an essential cytokine in the early stages of hematopoiesis because stimulates cell proliferation

C-Kit; aka Stem Cell Factor

8

what does GM-csf stand for?

Granulocyte Macrophage

9

What does Meg-csf stand for?

Megakaryocyte

10

what does G-csf stand for?

Granulocyte

11

What does M-csf stand for?

Monocyte

12

How can colony stimulating factors be used in patient care?

To start production of different cell lines

13

Cytokines that exhibit multiple biologic activities including regulation of autoimmune and infammatory reactions and hematopoiesis

Interleukins

14

2 examples of interleukins

IL-3 and IL-6

15

Interleukin that controls production, differentiation, and function of granulocytes and macrophages

IL-3

16

Interleukin that stimulates myeloid and lymphoid cell linneages

IL-6

17

programmed cell death

apoptosis

18

accidental cell death

necrosis

19

as cell matures what two things happen?

Decrease in cell size and decrease in N:C ratio

20

What specific changes occur in the nucleus during cell maturation?

loss of nucleoli, decrease in size, condensation of chromatin, possible shape changes, possible nucleus ejections

21

What specific changes occur in the cytoplasm during cell maturation?

Decrease in basophilia, increase in amount of cytoplasm, and granules may appear

22

This cell has a nucleus with 2-5 nucleoli, moderate basophilia with less than 5 granules, and is not present in peripheral blood; these cells are increased in leukemia

Myeloblast

23

These cells have a round to oval nucleus with 1-3 or more nucleoli, slightly coarser chromatin than myeloblast, basophilic cytoplasm with few red to purple primary granules and no secondary granules; these are not present in peripheral blood under normal conditions

Promyelocyte

24

Primary granules are composed of ________

Myeloperoxidase

25

Secondary granules are composed of _______

LAP

26

These cells have a round to oval nucleus that may have one flattened side, nucleoli not ususally visible, coarse chromatin, and is more condensed that promyelo; the cytoplasm is slightly basophilic but starting to turn pink due to granules; these are not present in peripheral blood under normal conditions

Myelocyte

27

This cell has an indented nucleus, nucleoli are not visible, and chromatin is coarse and clumped; cytoplasm is pink; not found in peripheral blood under normal conditions

Metamyelocyte

28

this cell has a band shaped nucleus which is constricted but no threadlike filament; cytoplasm is pink; and ______% are found in peripheral blood

Band; 0-6%

29

This cell's nucleus has 2-5 lobes connected by thin filaments and is found in the peripheral blood as _______%

Seg; 50-70%