Introduction to Leukocyte Neoplasms (Part 2 Acute Leukemias ALL) Flashcards Preview

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Flashcards in Introduction to Leukocyte Neoplasms (Part 2 Acute Leukemias ALL) Deck (18)
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1

Acute Leukemia
- Etiology (5)

- Oncogenic Viruses
- Genetic and congenital Factors
- Ionizing Radiation
- Chemical Agents
- Unknown

2

Acute Leukemia
- Bone marrow production

Reduced Bone Marrow Production
- Erythrocytes ----> Anemia
- Granulocytes ---> Neutropenia
- Platelets ----------> Thrombocytopenia

3

Bone Marrow Failure causes what three things in acute leukemia

- Anemia
- Infection
- Hemorrhage

4

Cell Growth occurs in what 4 tissues in acute leukemias

- Parenchymal Organs/Skin
- Thymus
- Cerebral Meninges
- Testes

5

What is the most common cancer of childhood (what type)?

B-Cell ALL

6

Acute Leukemias:
- Morphology

- Decreased platelets, anemia (due to BM failure)
- Blast Cells
- Auer Rods (in some MYELOID never LYMPHOID)

7

If you have greater than 20% blast in the PB or BM what does that mean?

That is the WHO classification for Acute Leukemias

8

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
- Most common in who?

Children

9

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
- onset between what years of age?

1-5 years of age

10

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
- What percentages fall within different white cell ranges

Normal WBC ---------> 25%
5-25 ---------------------> 50%
>100 ---------------------> 10%

11

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
- Purpose of immunophenotyping

- Distinguish blasts as lymphocytic in origin and not myeloid
- Distinguish between B Cell or T Cell
- Determines maturity of B or T cells

12

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
- Cytochemistry

- Myeloperoxidase: Negative
- Sudan Black B: Negative
- ANBe: Positive/Negative focal
- Periodic Acid Schiff: may be positive with BLOCK positivity

13

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
- Morphology

- Anemia
- Thombocytopenia
- Blasts +/-
- small blasts, more common usually pre B-Cell
- large blasts, usually pre T-Cell

14

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
- Immuntophenotyping for B Cell Leukemias and T Cell Leukemias

B: CD10+, CD19+, CD20+/-
T: CD2+, CD3+, CD4+, CD5+, CD7+; CD8+

15

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
- Terminology used in B Cell Leukemia list in order

Pro B-Cell
Pre-Pre B-Cell
Pre B-Cell

16

T cell leukemias always involve the _____ ______ and frequently develop lesions in _____ _____or other organs

Bone Marrow
Lymph Nodes

17

T-ALL patients have increased risk for what?

- risk for induction failure
- early relapse
- isolated CNS relapse

18

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
- Prognosis

- Depends upon lineage, cytogenetics, cell burden, and organomegaly
- survival is >85%
- poor prognosis if <1 year of age