Introduction to Leukocyte Neoplasms (Part 3 AML) Flashcards Preview

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Flashcards in Introduction to Leukocyte Neoplasms (Part 3 AML) Deck (55)
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1

Acute Myeloid Leukemia (AML) affects elements in what cell lineages?

granulocytic, monocytic, erythroid, or megakaryocytic lineages

2

Acute Myeloid Leukemia (AML) affects what age group?

All ages, predominated in adults around 65 years of age

3

How will someone present clinically with Acute Myeloid Leukemia (AML)?

- Pallor, fatigue
- Fever/ infection
- Bruising/ bleeding
- Malignant cell infiltration into other tissues

4

Acute Myeloid Leukemia (AML)
- peripheral blood

- Variable leukocytosis
- variable displasia
- myeloblasts present in 95% of patients
- Leukemic hiatus

5

Having many myeloblasts and some segs with no intermediate stages is known as what?

Leukemic Hiatus

6

Acute Myeloid Leukemia (AML)
- Bone marrow findings

- Hypercellular increased blasts
- >20% blasts with limited maturation
- variable dysplasia

7

Acute Myeloid Leukemia (AML)
- Immunophenotyping

CD34+, HLA-DR+, CD117+, CD13+, CD33+
(the last two are very specific to AML)

8

What six immature cells will you find in Acute Myeloid Leukemia (AML)?

- Myeloblasts
- Promyelocytes
- Monoblasts
- Promonocytes
- Erythroblasts
- Megakaryoblasts

9

Acute Myeloid Leukemia (AML) will have recurrent cytogenic abnormalities:
_______ - addition or deletion of part of - or entire- chromosome
_______ primarily translocations and inversions

Numerical
Structural

10

Acute Promyelocytic Leukemia (APL)
- cytogenetic abnormality

t(15;17)(q24;q21)

11

Acute Promyelocytic Leukemia (APL)
- two different types of APL

- Typical (60-70%)
- Atypical (30-40%)

12

Of the two types of APL...which one has hyper granular promyelocytes and nuclei are often bi-lobed or kidney shaped

Typical

13

Of the two types of APL...which one has micro granular promyelocytes and nuclei that are predominately deeply notched/bilobed (Butterfly)

Atypical

14

Will Acute Promyelocytic Leukemia (APL) have Auer rods?

YES! They will have multiple Auer Rods (faggot cells)

15

In Acute Promyelocytic Leukemia (APL), t(15;17) creates a fusion gene. What is it?

PML-RARA

16

The PML-RARA fusion gene leads to what?

Uncontrolled proliferation and inhibition of cellular differentiation

17

Acute Promyelocytic Leukemia (APL)
- Lab Results

- DIC/fibrinolysis coagulation
- Thrombocytopenia
- hyper or microgranular promyelocytes

18

When a slide from a patient with APL is stained with MPO, what will it look like?

Strongly Positive

19

Acute Promyelocytic Leukemia (APL)
- Treatment

- Prescribe ATRA
- manage coagulopathy

20

AML - With Abnormal Marrow Eosinophils
- cytogenetic abnormality

inv(16)(p13.1;q22)
t(16;16) (p13.1;q22)

21

AML - With Abnormal Marrow Eosinophils
- age group affected

primarily young adults

22

AML - With Abnormal Marrow Eosinophils
- prognosis

favorable to average risk

23

AML - With Abnormal Marrow Eosinophils
- Peripheral Blood findings

- myeloblasts (other immature myeloid cells)
- monocytoid cells
- thrombocytopenia
- normal eos

24

AML - With Abnormal Marrow Eosinophils
- Bone marrow findings

- myeloblasts and promyelocytes (30-80%)
- Monocytic component (>20%)
- >5% eosinophils (all stages of maturation)

25

AML with maturation
- cytogenetic abnormality

t(8;21)(q22;q22)

26

AML with maturation
- fusion gene

Runx1-Runx1T1

27

AML with maturation
- age affected

- 25-30 years old
- predominant in children and young adults

28

AML with maturation
- prognosis

- good in adults but poor in children
- response well with chemotherapy

29

AML with maturation
- PB findings

- Blasts with numerous azurophilic granules
- Some may have very large granules (Pseudo-Chediak-Higashi)
- Auer Rods likely

30

AML with maturation
- BM findings

dysplasia in neutrophil line
(monos, eos, and eryth, components not affected)