ITP vs TTP vs DIC Flashcards
(19 cards)
What is ITP?
Immune thrombocytopenic purpura
What happens to platelets with ITP?
Hypocoagulation due to autoimmune destruction of platelets.
What type of ITP is most common in which age group?
Chronic; women and adults 20-50
What causes ITP?
Idiopathic, autoimmune steroids, immunoglobulin infusions, plasma platelet transfusions, immunosuppressant therapy
How is ITP diagnosed?
With a complete blood count (platelets <20,000/mL)
What is TTP
Thrombotic thrombocytopenic purpura
What happens to platelets with TTP?
Hypercoagulation that depletes platelet levels
Which disease of the platelets is non-immunologic?
TTP
What is TTP caused by?
A deficiency in the zyme that cleaves von Willebrand’s factor
What causes TTP?
Idiopathic, hereditary, bone marrow transplant, cancer, medications, pregnancy, HIV
What will TTP look like at the cellular level?
Mutation on ADAMTS 13 gene
Anemia, thrombocytopenia, organ ischemia, memory changes, confusion, jaundice, heart failure/ myocardial infaction are manifestations of which platelet disease?
TTP
Which platelet disease requires plasmapheresis, splenectomy, glucocorticoid steroids, and immunosuppresents?
TTP
Which of the following is the most common hereditary bleeding disorder?
A. Von Willebrand’s disease
B. DIC
C. ITP
D. TTP
A. Von Willebrand’s disease
Which disease of the platelets is a life threatening complication of many conditions springing from an inappropriate immune response?
DIC
What happens during DIC?
Widespread coagulation
Massive bleeding due to the depletion of clotting factors
What causes DIC?
Blood transfusion reaction, cancer, sepsis, OB complications, venomous snake bite
Tissue ischemia, and abnormal bleeding are manifesations of which platelet disease?
DIC
Which platelet disease requires identification and treatment of underlying cause, replenishment of clotting components, and treatment of bleeding?
DIC
