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Y4R6 - Pediatrics II 👶 > L2: Bleeding Disorders - Thromboasthenia & Clotting Disorders > Flashcards

L2: Bleeding Disorders - Thromboasthenia & Clotting Disorders Flashcards

(65 cards)

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1
Q

Platlet Function Defect

A

Thromboasthenia

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2
Q

Etiology of Thromboasthenia

A
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3
Q

Etiology of Thromboasthenia

  • Congenital
A
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4
Q

Etiology of Thromboasthenia

  • Acquired
A
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5
Q

TTT of Thromboasthenia

A
  1. PLT transfusion.
  2. Antioxidant (e.g. Vitamin C or E).
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6
Q

Incidence of Glanzmann thrombasthenia

A

It is the 3d most common inherited bleeding disorder

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7
Q

Pathogenesis of Glanzmann thrombasthenia

A

It’s caused by a deficiency of the platelet integrin alpha llb beta3.
- This integrin is the platelet fibrinogen receptor and is thus essential to platelet aggregation and hemostasis.

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8
Q

TTT of Glanzmann thrombasthenia

A
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9
Q

most common cause of purpura

A

Thrombocytopenia

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10
Q

most common cause of thrombocytopenic purpura

A

ITP

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11
Q

most common cause of nonthrombocytopenic purpura

A

Anaphylactoid purpura

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12
Q

Diagnostic approach to a patient with mucocutaneous bleeding (purpuric disorders)

A
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13
Q

Introduction to the process of Coagulation

A
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14
Q

Phases of Blood Coagulation

A
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15
Q

Phases of Blood Coagulation

  • Phase 1
A
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16
Q

Phases of Blood Coagulation

  • Phase 2
A
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17
Q

Phases of Blood Coagulation

  • Phase 3
A
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18
Q

Phases of Blood Coagulation

  • Phase 4
A

Soft clot → Hard clot

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19
Q

Bleeding Time

  • Def
  • Affected By
  • Normal
A
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20
Q

Clotting Time

  • Def
  • Affected By
  • Normal
A
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21
Q

PT

  • Def
  • Affected By
  • Normal
A
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22
Q

APTT

  • Def
  • Affected By
  • Normal
A
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23
Q

Thrombin Time

  • Def
  • Affected By
  • Normal
A
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24
Q

Clotting Disorders

A
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25
Types of **Hemophilia**
26
Incidence of **Hemophilia A**
The most commo hereditary coagulation disorder
27
Inheritance in **Hemophilia A**
X-linked recessive - so it affects males mainly & females are carrier
28
Etiology of **Hemophilia A**
29
Degrees of **Hemophilia A**
30
CP of **Hemophilia A**
31
INVx for **Hemophilia A**
32
INVx for **Hemophilia A**
33
INVx for **Hemophilia A** - Bleeding Time
Normal
34
INVx for **Hemophilia A** - Clotting time
Prolonged
35
INVx for **Hemophilia A** - APTT
Prolonged
36
INVx for **Hemophilia A** - PT
Normal
37
INVx for **Hemophilia A** - Specific Factor Assay
Deficiency of factor VIII
38
INVx for **Hemophilia A** - Thromboplastic Generation Test
Defective test "deficiency of factor VIII"
39
INVx for **Hemophilia A** - joimt X-Ray & CT
For hemoarthrosis
40
INVx for **Hemophilia A** - Prenatal Dx
By amniocentesis or chorionic villous sampling
41
TTT of **Hemophilia A**
42
TTT of **Hemophilia A** - general Measures
43
TTT of **Hemophilia A** - hemoarthrosis
44
TTT of **Hemophilia A** - replacment Therapy
45
Replacment Therapy in **Hemophilia A** - Fresh Blood Transfusion
46
Replacment Therapy in **Hemophilia A** - Fresh Frozen Plasma
47
Replacment Therapy in **Hemophilia A** - Cryo PPt
48
Replacment Therapy in **Hemophilia A** - Factor VIII Conc.
49
Replacment Therapy in **Hemophilia A** - Factor VIII Recombinant
50
Replacment Therapy in **Hemophilia A** - desmopressin "DDAVP"
51
Another name of **VWD**
Pseudo Hemophilia - Vascular
52
Def of **VWD**
Congenital disorder comprises both coagulation and platelet function defects
53
Incidence of **VWD**
The most common hereditary bleeding disorder (1-2% of population).
54
Inheritance of **VWD**
Autosomal dominant disease (mainly)
55
ETIOLOGY OF **VWD**
Deficiency of von willbrand factor
56
Function of **VWF**
1. Platelet adhesion. 2. It binds & transports factor VIII (protecting it from degradation).
57
Types of **VWD**
58
Types of **VWD** - Type 1
59
Types of **VWD** - Type 2
60
Types of **VWD** - Type 3
61
Types of **VWD** - Platlet Type
62
CP of **VWD**
As hemophilia + Purpura
63
INVx for **VWD**
64
TTT of **VWD**
65
Scheme for Bleeding Disorders

Y4R6 - Pediatrics II 👶 (72 decks)

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