Flashcards in Lecture 20/21 - CHF Drugs Deck (114)
What major molecule controls the contractility of the heart?
What six aspects can be alter cardiac contractility?
Sensitivity to Ca
Amount of Ca released from SR
Amount stored in SR
Amount of trigger Ca
Na/Ca exchanger activity
Intracellular Na concentration
What are the four components of cardiac performance?
What occurs in cardiogenic shock in regards to stroke work?
even with LV filling pressure increasing heart can't counteract with increased work force
What are the three aspects of pressure of fluid movement within the capillaries?
What is normal transudation pressure?
10 to 15 mmHg
Drug type that works on: Decreased CO
Positive inotropic drugs
Drug type that works on: Na + Water retention
Drug type that works on: RAA system
Drug type that works on: Cardiac remodeling
ACE inhibitors + B-blockers
Drug type that works on: Congestion + Edema
Drug type that works on: Increased venous volume + pressure
Drug type that works on: Increased afterload
What are the nine drug groups that can be used to treat CHF, or other cardiac conditions? (nine)
Calcium channel blockers
List the drugs: Diuretics
List the drugs: ACE inhibitors
List the drugs: Calcium sensitizer
List the drugs: Digitalis
List the drugs: Sympathomimetics
List the drugs: Inodilators
List the drugs: Beta Blockers
List the drugs: A/B blockers
List the drugs: Calcium channel blockers
What characterizes CHF?
High cardiac filling pressure -->
Leading to venous congestion + Tissue fluid accumulation
Where, in regards to the CHF, does venous congestion occur?
Behind the affected side of the heart
What condition normally underlies CHF that can cause further progression of the disease?
What can stimulate compensatory mechanisms to begin in CHF?
Chronic cardiac overload (Volume or Pressure)
What are the major signs of left-sided CHF?
Pulmonary venous congestion + edema
Cough + Pulmonary crackles + etc.
What occurs with chronic pulmonary venous congestion?
Sometimes right sided CHF can begin