Lecture 20/21 - CHF Drugs Flashcards Preview

Pharmacology I > Lecture 20/21 - CHF Drugs > Flashcards

Flashcards in Lecture 20/21 - CHF Drugs Deck (114)
Loading flashcards...
1

What major molecule controls the contractility of the heart?

Calcium

2

What six aspects can be alter cardiac contractility?

Sensitivity to Ca
Amount of Ca released from SR
Amount stored in SR
Amount of trigger Ca
Na/Ca exchanger activity
Intracellular Na concentration

3

What are the four components of cardiac performance?

Preload
Afterload
Contractility
Heart rate

4

What occurs in cardiogenic shock in regards to stroke work?

even with LV filling pressure increasing heart can't counteract with increased work force

5

What are the three aspects of pressure of fluid movement within the capillaries?

Hydrostatic
Colloid
Tissue

6

What is normal transudation pressure?

10 to 15 mmHg

7

Drug type that works on: Decreased CO

Positive inotropic drugs

8

Drug type that works on: Na + Water retention

Diuretics

9

Drug type that works on: RAA system

ACE inhibitors

10

Drug type that works on: Cardiac remodeling

ACE inhibitors + B-blockers

11

Drug type that works on: Congestion + Edema

Diuretics

12

Drug type that works on: Increased venous volume + pressure

Vasodilators

13

Drug type that works on: Increased afterload

Vasodilators

14

What are the nine drug groups that can be used to treat CHF, or other cardiac conditions? (nine)

Diuretic
ACE inhibitors
Calcium sensitizers
Digitalis
Sympathomimetics
Inodilators
Beta blockers
Alpha/Beta blockers
Calcium channel blockers

15

List the drugs: Diuretics

Furosemide
Spironolactone
Hydrochlortiazide

16

List the drugs: ACE inhibitors

"-prils"
Enalapril
Benazepril
Captopril

17

List the drugs: Calcium sensitizer

Pimobendan

18

List the drugs: Digitalis

Digoxin

19

List the drugs: Sympathomimetics

Dobutamine
Dopamine

20

List the drugs: Inodilators

"-nones"
Amrinone
Milrinone

21

List the drugs: Beta Blockers

"-olol"
Atenolol
Propranolol
Metoprolol

22

List the drugs: A/B blockers

Carvedilol

23

List the drugs: Calcium channel blockers

Diltiazem

24

What characterizes CHF?

High cardiac filling pressure -->
Leading to venous congestion + Tissue fluid accumulation

25

Where, in regards to the CHF, does venous congestion occur?

Behind the affected side of the heart

26

What condition normally underlies CHF that can cause further progression of the disease?

Poor contractility

27

What can stimulate compensatory mechanisms to begin in CHF?

Chronic cardiac overload (Volume or Pressure)

28

What are the major signs of left-sided CHF?

Pulmonary venous congestion + edema
Cough + Pulmonary crackles + etc.

29

What occurs with chronic pulmonary venous congestion?

Pulmonary hypertension
Sometimes right sided CHF can begin

30

What are the major consequences of right-sided CHF?

Systemic venous hypertension
Jugular venous distension
Hepatic congestion + Pleural effusion