Lecture 14/15 - Adrenergic Stimulants Flashcards Preview

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Flashcards in Lecture 14/15 - Adrenergic Stimulants Deck (99)
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1

What are the catecholamines? (three)

Epinepherine
Norepinephrine
Isoproterenol

2

What is the beta1 agonist?

Dobutamine

3

What is the beta2 agonist?

Albuterol

4

What is the alpha agonist?

Phenylphrine

5

What are the alpha2 agonists? (four)

Xylazine
Detomidine
Medetomidine
Dexmedetomidine

6

What are three other adrenergic stimulants that aren't really receptor related?

Amphetamine
Cocaine
Tyramine

7

Where is NE released from?

Nerves + Adrenal medulla

8

What does NE stimulate?

Alpha + B1

9

Where is EPI released from?

Adrenal medulla

10

What does EPI stimulate?

Alpha + Beta

11

What inhibits tyrosine hydroxylase?

Metyrosine

12

What is the basic progression of Tyrosine to Epi?

Tyrosine - L-DOPA - Dopamine - NE - EPI

13

What are the two way that NE/EPI/ISO are metabolized?

MAO - in nerve
COMT - in circulation

14

What two drugs stimulate NE release?

Amphetamines + Tyramine

15

What does cocaine do in the adrenergic terminal?

Inhibit NE reuptake

16

What compound would you test to test NE levels in the body?

VMA levels in urine

17

What does SNS stimulation of Alpha1 do?

Vasoconstriction

18

What does SNS stimulation of Beta1 do?

Increase heart rate + contractility
Renin secretion

19

What does SNS stimulation of Beta2 do?

Vasodilation of skeletal muscle BV
Glycogenolysis

20

What does SNS stimulation of Beta3 do?

Lipolysis

21

What does SNS stimulation of Alpha2 do?

Inhibit NE release (or any NT)

22

What occurs with indirect acting drug when denervation happens?

No longer work

23

What occurs with direct acting drugs when denervation occurs?

Increase activity possible

24

What makes up NE?

Dopamine + hydroxyl group

25

What does NE stimulate?

Alpha + B1

26

What makes up EPI?

NE + Methyl group

27

What does EPI stimulate?

Alpha + Beta

28

What makes up Isoproterenol?

EPI + 2 methyl groups

29

What does isoproterenol stimulate?

Betas

30

Where is isoproterenol found in the body?

Not, synthetically made drug