Lecture 2/3 - Pharmacokinetics Flashcards Preview

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Flashcards in Lecture 2/3 - Pharmacokinetics Deck (92)
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1

What are the two methods of passive transport?

Channel mediated + Transporter mediated

2

What are three major components that go with carrier mediated transport?

Structure specific
Competition
Tmax

3

What are the two methods of carrier mediated methods?

Facilitated diffusion + Active transport

4

What is different about active transport compared to facilitated diffusion?

This method needs ATP in order to function

5

What is transcytosis?

Drug molecules + fluids are engulfed by the cell membrane and transported within the cell

6

What is the pH of most drugs given?

Weak acids or Weak bases

7

What is the most basic process that drugs undergo within the body ? (Hint: decides whether they are absorbed or not)

Ionization - phH dependent

8

What is the purpose of the Henderson-Hasselbach equation?

Tells you to what extent the drug is ionized within the body

9

What is A- form of the acid?

Ionized form

10

What is the HA form of the acid?

Unionized form

11

What is the B form of a base?

Unionized form

12

What is the BH+ form of a base?

Ionized form

13

What occurs to a weak acid within an acidic medium?

Less ionized
More lipid soluble
Rapidly absorbed

14

What occurs with a weak basic drug within basic medium?

Less ionized
Rapidly absorbed

15

What is an example, given in lecture, of an area with low pH?

The stomach (~2)

16

What is an example, given in lecture, of an area in the body with basic tendencies?

The intestines

17

What occurs when a basic drug is within an acid medium? What is this called?

Ionized and therefore will accumulate within the area. Known as ion trapping

18

What is the rule of thumb with both strong acids and bases within the body?

Always will be ionized within the body, so they are not lipid soluble meaning they will not undergo passive diffusion

19

What is the basic understanding of ion trapping?

Acids will be stuck in basic environments
Bases will be stuck in acidic environments

20

How do you make urine more acidic?

Ammonium chloride

21

How do you make urine more basic?

Sodium bicarbonate

22

What happens when you make urine more acidic?

Increase the elimination of bases via ion trapping

23

What happens when you make the urine more basic?

Increased elimination of acids, via ion trapping

24

What are the three types of active transport?

Uniport + Symport + Antiport

25

What is an example of a uniport given in lecture?

H+

26

What is an example of a symport given in lecture?

Glucose uptake

27

What is an example of an antiport given in the lecture?

Na/K ATPase

28

What is P-gp?

Permeability glycoprotein

29

What are two other names for P-gp?

MDRI
-- or --
ABCBI

30

What is the function of P-gp?

Utilizes ATP to pump out a WIDE variety of drugs across both extra/intracellular membranes