Flashcards in Lecture 2/3 - Pharmacokinetics Deck (92)
What are the two methods of passive transport?
Channel mediated + Transporter mediated
What are three major components that go with carrier mediated transport?
What are the two methods of carrier mediated methods?
Facilitated diffusion + Active transport
What is different about active transport compared to facilitated diffusion?
This method needs ATP in order to function
What is transcytosis?
Drug molecules + fluids are engulfed by the cell membrane and transported within the cell
What is the pH of most drugs given?
Weak acids or Weak bases
What is the most basic process that drugs undergo within the body ? (Hint: decides whether they are absorbed or not)
Ionization - phH dependent
What is the purpose of the Henderson-Hasselbach equation?
Tells you to what extent the drug is ionized within the body
What is A- form of the acid?
What is the HA form of the acid?
What is the B form of a base?
What is the BH+ form of a base?
What occurs to a weak acid within an acidic medium?
More lipid soluble
What occurs with a weak basic drug within basic medium?
What is an example, given in lecture, of an area with low pH?
The stomach (~2)
What is an example, given in lecture, of an area in the body with basic tendencies?
What occurs when a basic drug is within an acid medium? What is this called?
Ionized and therefore will accumulate within the area. Known as ion trapping
What is the rule of thumb with both strong acids and bases within the body?
Always will be ionized within the body, so they are not lipid soluble meaning they will not undergo passive diffusion
What is the basic understanding of ion trapping?
Acids will be stuck in basic environments
Bases will be stuck in acidic environments
How do you make urine more acidic?
How do you make urine more basic?
What happens when you make urine more acidic?
Increase the elimination of bases via ion trapping
What happens when you make the urine more basic?
Increased elimination of acids, via ion trapping
What are the three types of active transport?
Uniport + Symport + Antiport
What is an example of a uniport given in lecture?
What is an example of a symport given in lecture?
What is an example of an antiport given in the lecture?
What is P-gp?
What are two other names for P-gp?
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