Flashcards in Lecture 22 - Vasodilators Deck (51)
What are the families of drugs used for vasodilation purposes?
Calcium Channel Antagonists
Alpha 1 Adrenergic antagonists
Drugs within Family: NO acting
Drugs within Family: Nitrate
Drugs within Family: Calcium channel antagonists
Drugs within Family: PDE5 inhibitors
Drugs within Family: Alpha-1 aderenergic antagonists
What does Gq cause to occur?
After PLC is activated by Gq what are the downstream effects?
PIP2 --> DAG + IP3
IP3 - dephosphorylated
DAG - broken down
Ca - pumped out
What does DAG go and do once activated?
What does IP3 do and do once it is activated?
Release Ca from intracellular storage
What are three ways that one can relax vascular smooth muscle?
decrease intracellular Ca
Increase cAMP in vascular cells
What drugs can increase cGMP?
PDE 5 inhibitors
What drugs can decrease intracellular Ca?
Calcium channel blcokers
Why is it preferred to have increased cAMP within the vascular cells?
cAMP = inactivation of myosin light chain kinase
What can vasodilators do that help some heart failure patients?
-- and --
Reduce edema + Effusion
What can drugs that reduce arterolar resistance be used for commonly?
What drugs can effect the walls of arteries and/or veins?
Vessels affected: ACEi
A = V
Vessels affected: Nitrates
Vessels affected: Hydralazine
Vessels affected: CCA's
A a lot
Vessels affected: Alpha-blockers
A = V
What is hydralazine commonly used for?
Mitral valve insufficency
What happens with hyralazine toxicity?
Vomiting + Anorexia + Tachycarida + Sweating +
Ischemic arrhythmia + Decomposition
What hydralazine side effect is seen in all animals besides dogs?
What do Nitrate compounds do chemically?
What do nitrates do within the cell?
Decrease the phosphorylation of light chain mysosin