Lecture 13 - Cholinergic Antagonists Flashcards Preview

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Flashcards in Lecture 13 - Cholinergic Antagonists Deck (71)
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1

What are the muscarinic antagonists? (six)

Atropine
Scopolamine
Glycopyrrolate
Oxybutynin
Ipratropium
Tropicamide

2

What are the non-depolarizing NMJ blocking agents? (five)

D-tubocurarine
Pancuronium
Vecuronium
Cisatracurium
Atracurium

3

What are the depolarizing NMJ blocking agents? (one)

Succinylcholine

4

What does atropine come from?

Belladona/nightshade

5

What does scopolamine come from?

angels trumpet

6

What is the general distribution of atropine?

Only gets into CNS with very high doses
Mostly peripheral effects

7

About how long does atropine last in dogs?

30 min

8

What is the general distribution of scopolamine?

CNS!

9

What effects do you see with scopolamine?

Euphoria + Sedation + Amnesia

10

What determines the effects of atropine at a certain organ?

Dose
Prevailing tone
Distribution of M receptors

11

How do rabbits react to atropine?

Resistant, have special enzyme to metabolize quickly

12

How do goats, cattle, and horses react to atropine?

Can eat the plant, but injected atropine can be VERY toxic

13

How do swine react to atropine?

very sensitive, can't even eat it

14

What are the general CNS effects of atropine?

Confusion + Coma

15

What are the toxic CNS effects of scopolamine?

Hallucinations + Delirium + Coma

16

What is the normal state of the eye?

PNS - slightly rounded lens + slightly constricted pupil

17

What does muscarinic antagonist do to the eye?

PNS decreased
Pupil dilated - via circular muscle
Lens flattens - via ciliary muscle

18

What is mydriasis?

Dilation

19

What is miosis?

Constriction

20

What side effects do you see with muscarinic blocked in the eye?

Photophobia + Blurry vision + Dry eyes

21

What type of muscarinic receptor is on the heart?

M2

22

What does M2 do at the heart?

ACh stimulates M2 on the heart at SA node
Pre-synaptic M2 decreases NE
Both decrease heart rate

23

What does muscarinic blockade due to the heart?

Tachycardia

24

When is atropine used in relation to the heart?

Cardiac arrest

25

What do cholinergic antagonists do to respiration?

Reverse bronchoconstriction
--or--
Bronchodilation

26

When is a cholinergic antagonist used in regards to respiration?

RAO or Heaves

27

What cholinergic antagonist is used for heaves?

Ipratropium

28

What does muscarinic blockade do in the GI tract?

Decrease motility + secretions
Decrease tone of bile duct

29

What does muscarinic blockade do to the bladder?

Decrease bladder motility
Decrease tone of ureter

30

What does muscarinic blockade do to the uterus?

Depress hypertonicity