Flashcards in Lecture 13 - Cholinergic Antagonists Deck (71)
What are the muscarinic antagonists? (six)
What are the non-depolarizing NMJ blocking agents? (five)
What are the depolarizing NMJ blocking agents? (one)
What does atropine come from?
What does scopolamine come from?
What is the general distribution of atropine?
Only gets into CNS with very high doses
Mostly peripheral effects
About how long does atropine last in dogs?
What is the general distribution of scopolamine?
What effects do you see with scopolamine?
Euphoria + Sedation + Amnesia
What determines the effects of atropine at a certain organ?
Distribution of M receptors
How do rabbits react to atropine?
Resistant, have special enzyme to metabolize quickly
How do goats, cattle, and horses react to atropine?
Can eat the plant, but injected atropine can be VERY toxic
How do swine react to atropine?
very sensitive, can't even eat it
What are the general CNS effects of atropine?
Confusion + Coma
What are the toxic CNS effects of scopolamine?
Hallucinations + Delirium + Coma
What is the normal state of the eye?
PNS - slightly rounded lens + slightly constricted pupil
What does muscarinic antagonist do to the eye?
Pupil dilated - via circular muscle
Lens flattens - via ciliary muscle
What is mydriasis?
What is miosis?
What side effects do you see with muscarinic blocked in the eye?
Photophobia + Blurry vision + Dry eyes
What type of muscarinic receptor is on the heart?
What does M2 do at the heart?
ACh stimulates M2 on the heart at SA node
Pre-synaptic M2 decreases NE
Both decrease heart rate
What does muscarinic blockade due to the heart?
When is atropine used in relation to the heart?
What do cholinergic antagonists do to respiration?
When is a cholinergic antagonist used in regards to respiration?
RAO or Heaves
What cholinergic antagonist is used for heaves?
What does muscarinic blockade do in the GI tract?
Decrease motility + secretions
Decrease tone of bile duct
What does muscarinic blockade do to the bladder?
Decrease bladder motility
Decrease tone of ureter