Flashcards in Lecture 29 - Anticoagulants + Hemostatic Deck (92)
What are examples of hypercoaguable states?
Acute phase inflammation
What are examples of a hypocoaguable state?
Genetic bleeding disorders
What are the three necessary components of a functional clotting system?
Production of clotting factors
Break down of clots
What is the breaking down of blood clots called
What interacts with blotting factors to induce the coagulation cascade?
What are the factors within the intrinsic pathway?
12 - 11 - 9 - 8
What are the factors within the extrinsic pathway?
Tissue factor - 7
Where are the extrinsic molecules located?
Wall of the blood vessel
What tests the extrinsic pathway?
What tests the intrinstic pathway?
What is part of the common pathway?
2 - 1
What is factor 2 known as?
What is factor I known as?
What does fibrinogen do?
Polymerizes into a clot
What are the factors that depend on Vitamin K?
2 - 7 - 9 - 10
How does vitamin K activate certain Factors in the coag pathway?
Reduced --> Oxidized state
with y-glutamyl carboxylase
What recycles y-glutamyl carboxylase back to reduced form?
Vitamin K epoxide reductase
What is warfarin used in, in an extra-label use manner?
Food animals + Horses
how is warfarin distributed throughout the body?
Via plasma protein
What are the differences that you see in 1/2 life of warfarin?
extremely long in cats
How is warfarin metabolized?
How is warfarin excreted?
Urine + Feces
Why is the use of warfarin complicated?
Very small theraputic index
What is seen with warfarin toxicity?
Fatal hemorrhade w/ anemia
Hematomas all over
Congenital malformation in dogs + cats
What are therapeutic complications seen with warfarin use?
Dogs tolerant within a month
Need frequent testing of PT
When do you see warfarin toxicity?
Moldy sweet clover + Sweet vernal hay
What is the biggest problem when it comes to warfarin toxicity in AZ?
Where does warfarin affect the coag pathway?
Vit. K epoxide reductase
Why does giving Vitamin K in Warfarin toxicity help the animal?
Concentration of Vitamin K now high enough it can bypass the reductase and use DL-diaphorase instead