Flashcards in Lecture 10 - Intro to ANS Deck (112):
Describe the ANS.
Describe the somatic nervous system.
What are all pre-synaptic terminals composed of? (receptor, NT)
ACh to Nicotinic
What are all PNS synapses composed of? (receptor, NT)
ACh to Muscarinic
What are all NMJ's composed of? (receptor, NT)
ACh to Nicotinic
What are three types of SNS receptors?
M + A/B + D
Where are SNS M found? What stimulates them?
Sweat glands, ACh
Where are SNS A/B receptors found? What stimulates them?
Cardiac + Smooth Muscle
Gland cells + Nerve terminals
Where are SNS D receptors found? What stimulates them?
Renal vascular SM
Where do PNS preganglionic fibers originate?
Midbrain + Medulla Oblongata + Sacral area
Are preganglionic fibers of PNS short or long?
Where do preganglionic fibers from SNS synapse?
Where do SNS preganglionic fibers originate?
Thoracic + Lumbar
What is special about the SNS in regards to having the paravertberal chain?
Can coordinate reactions
What does SNS NE act on?
Alpha + Beta1 receptors
What does the epinephrine from adrenal medulla act on receptor wise?
Alpha + Beta
List all the places (we need to know) that ACh is released from.
SNS to sweat glands
Adrenal medulla innervation
List all the places (we need to know) that NE is released.
Most port-ganglionic SNS
What is acetylcholine made from?
Choline + Acetyl CoA
What enzyme makes ACh?
Describe how cholinergic transmission occurs.
Choline enters cell via CHT (w/ Na)
ChAT makes ACh
VAT takes in ACh into vesicle
Stimulus occurs - vesicle is released
ACh broken down via AChE
Choline take back up into nerve terminal
Describe how adrenergic transmission occurs.
Tyrosine enters cell (w/ Na)
Tyrosine hydroxylase makes L-DOPA
L-DOPA becomes Dopamine
VMAT take dopamine into the vesicle
Dopamine becomes NE
Stimulus causes NE release
NE taken back into cell via NET
What drug inhibits Tyrosine hydroxylase?
What drug depletes NE from vesicle?
What drugs inhibit NET?
Cocaine + Antidepressants
What drugs inhibit CHT?
What drugs inhibit VAT?
What toxin inhibits ACh release?
What do amphetamines do to adrenergic transmission?
Reverse transport to increase release
What two enzymes metabolize NE?
MAO + COMT
What are the four cholinergic receptors?
M1-3 + N
Where is M1 found?
Sweat glands + CNS
Where is M2 found?
Pre-synaptic nerve terminals
Where is M3 found?
Where are N receptors found?
What receptor does M1 + M3 interact with? What does it do?
Increase PLC + IP3 + DAG
What receptor does M2 interact with? What does it do?
What kind of receptor are nicotinic receptors?
Where are alpha1 receptors found?
What receptor type is alpha1 related to? What does it do?
Increase PLC + IP3 + DAG
Ca2+ increases = cell depolarizes
What receptor type is alpha2 related to? What does it do?
Where is alpha2 found?
What receptor does ALL betas interact with? What do they do?
Where are beta1 receptors found?
What is the general effect of beta1?
Increase HR + Force of contraction
Where are beta2 receptors found?
Bronchioles + Heart + SM in skeletal blood vessels
Where are beta3 receptors found?
Fat cells + Bladder
What is the general effect of beta3?
How many dopamine receptors are there?
Where are D1 + D5 receptors found?
Brain + Vascular beds
What is the typical response (molecularly) to D1 or D5 stimulus?
Where are D2-4 found?
Brain and other tissues
What is the typical response (molecularly) to D2-4 stimulus?
What are the three pre-synaptic regulatory receptors?
Alpha2 + Beta + M2
What do pre-synaptic alpha2 receptors inhibit?
What do pre-synaptic beta receptors do?
Increase NE release
What do pre-synaptic M2 receptors do?
Inhibit NE release
What type of receptor is M2 consider when it is pre-synaptic?
What type of receptor is Beta when it is pre-synaptic?
What molecule takes part in endocytosis of an activated receptor?
What are the two places with NO PNS?
Blood vessels + Sweat glands
What are the VERY basic characteristics of PNS function?
rest and digest
Necessary for life
What are the VERY basic characteristics of SNS function?
Fight or flight
Respond to stress
With PNS stimulation what happens with heart rate?
With PNS stimulation what happens with secretions?
Gastric + Salivation increase
With PNS stimulation what happens with GI activity?
With PNS stimulation what happens with GI sphincters?
With PNS stimulation what happens with pupils?
With PNS stimulation what happens with accommodation for eyes?
With SNS stimulation what happens with heart rate?
With SNS stimulation what happens with blood vessels to muscles?
With SNS stimulation what happens with bronchioles?
With SNS stimulation what happens with GI?
Less active, sphincters contract
With SNS stimulation what happens with eyes?
Pupils dilate + accommodation for distance
With SNS stimulation what happens with metabolism?
Increase lipolysis + blood sugar
With SNS stimulation what happens with the kidneys?
Increase renin secretion
What 4 things occur in the Heart, BV, and lungs with PNS stimulus?
Decrease heart rate
Decrease atrioventricular conduction
What 4 things occur in the Heart, BV, and lungs with SNS stimulus?
Increase heart rate
Increase Atrioventicular conduction
What does M2 do in the heart?
Decrease heart rate + conduction
What does M3 do in the heart, blood vessels, and lungs?
What does B2 do in the heart, blood vessels, and lungs?
Relax BV to skeletal muscles
(small effect on heart rate)
What does B1 do in the heart, blood vessels, and lungs?
Increase HR + AV conduction + Contraction
What does alpha1 do in the heart, blood vessels, and lungs?
Constrict most other BV in the body
Why do you see an increase then a decrease in HR with SNS stimulation?
Baroreceptors keep heart rate in check
What do baroreceptors monitor?
Where do baroreceptors send their message?
VMC in medulla
Where are baroreceptors located?
Aortic arch + Carotid artery
What two things do NE stimulate that cause an increase in BP?
alpha = Vasoconstriction
B1 = Increase HR
What changes diastolic pressure?
Vasoconstriction (alpha stimulus)
What changes systolic pressure?
Difference between CO + vasoconstriction
What are the general PNS effects on the GI tract?
Hydrochloric acid secretion increased
What receptor works on the GI tract via PNS?
What are the general effects of SNS on GI tract?
What receptor from SNS is responsible for increased glycogenolysis?
What SNS receptor is responsible for relaxing the GI tract?
Alpha2 + Beta2
What are the PNS effects on the Gentiourinary tract?
Urination = contract bladder + relax sphincters
What does B1 do in the gentiourinary tract?
What does B2 do in the gentiourinary tract?
Relax bladder wall + uterus
What does A2 do in the gentiourinary tract?
Contract sphincters - Ejaculation
What are the PNS effects in the eyes?
What are the SNS effects in the eyes?
What receptors acts in the eyes for the SNS?
Is PNS vision near or far?
What muscle controls accommodation?
What is the shape of the lens for near vision?
What receptors constrict the ciliary muscle?
Which pupil muscle is SNS?
What pupil muscle is PNS?
What receptor is on the circular muscle?
What receptor is on the radial muscle?
What are the muscarinic effects on the eye?
Iris circular muscle = Constriction
Ciliary muscle = Accomodation (near)
Decrease pressure = outflow of aqueous humor