Flashcards in Lecture 10 - Intro to ANS Deck (112)
Describe the ANS.
Describe the somatic nervous system.
What are all pre-synaptic terminals composed of? (receptor, NT)
ACh to Nicotinic
What are all PNS synapses composed of? (receptor, NT)
ACh to Muscarinic
What are all NMJ's composed of? (receptor, NT)
ACh to Nicotinic
What are three types of SNS receptors?
M + A/B + D
Where are SNS M found? What stimulates them?
Sweat glands, ACh
Where are SNS A/B receptors found? What stimulates them?
Cardiac + Smooth Muscle
Gland cells + Nerve terminals
Where are SNS D receptors found? What stimulates them?
Renal vascular SM
Where do PNS preganglionic fibers originate?
Midbrain + Medulla Oblongata + Sacral area
Are preganglionic fibers of PNS short or long?
Where do preganglionic fibers from SNS synapse?
Where do SNS preganglionic fibers originate?
Thoracic + Lumbar
What is special about the SNS in regards to having the paravertberal chain?
Can coordinate reactions
What does SNS NE act on?
Alpha + Beta1 receptors
What does the epinephrine from adrenal medulla act on receptor wise?
Alpha + Beta
List all the places (we need to know) that ACh is released from.
SNS to sweat glands
Adrenal medulla innervation
List all the places (we need to know) that NE is released.
Most port-ganglionic SNS
What is acetylcholine made from?
Choline + Acetyl CoA
What enzyme makes ACh?
Describe how cholinergic transmission occurs.
Choline enters cell via CHT (w/ Na)
ChAT makes ACh
VAT takes in ACh into vesicle
Stimulus occurs - vesicle is released
ACh broken down via AChE
Choline take back up into nerve terminal
Describe how adrenergic transmission occurs.
Tyrosine enters cell (w/ Na)
Tyrosine hydroxylase makes L-DOPA
L-DOPA becomes Dopamine
VMAT take dopamine into the vesicle
Dopamine becomes NE
Stimulus causes NE release
NE taken back into cell via NET
What drug inhibits Tyrosine hydroxylase?
What drug depletes NE from vesicle?
What drugs inhibit NET?
Cocaine + Antidepressants
What drugs inhibit CHT?
What drugs inhibit VAT?
What toxin inhibits ACh release?
What do amphetamines do to adrenergic transmission?
Reverse transport to increase release