Flashcards in Lecture 16 - Adrenergic blocking agents Deck (65)
What are the alpha-receptor blockers? (two)
What are the Alpha1 blockers? (one)
What is the alpha2 blocker?
What are the beta blockers? (three)
What are the beta1 blockers?
What is the general distribution of alpha receptors?
What does alpha 1 cause?
Contraction of genitourinary muscle
What does alpha2 cause?
decrease NE release
Suppress insulin secretion
What does alpha blockade do you cardiovascular system?
Decrease peripheral resistance = Decrease D pressure
= decrease BP
Decrease venous return = othrostatic hypotension
What does alpha blockade do to the eyes?
Miosis (via lack of radial muscle stimulation)
What happens to the nasal passages with alpha blockade?
Nasal congestion due to decreased vasoconstriction
What happens to urinary flow with alpha blockade?
urine flow increases
Base of bladder + urinary sphincter + prostate relax
What happens to sexual reproduction with alpha blockade?
What do alpha2 blocking agents do?
Increase NE release
What is the basic distribution of beta receptors?
What does the B1 receptor do? (two things)
Increase heart rate and force
Increase renin secretion
What does B2 stimulation cause? (four things)
Dilate BV supplying skeletal muscles
Increase aqueous humor + intraocular pressure
What does B2 stimulation cause?
What are the basic three things that occur with beta blockade in the heart and kidney ?
Decrease in HR and force
Decrease in CO and O2 demand
Decrease in renin secretion
What will happen overtime with beta blockade?
Decrease in BP in patients with hypertension
What does beta blockade cause with metabolism?
Decrease glycogenolysis + lipolysis
What is the behavior of a competitive antagonist?
If enough agonist is present can reach Emax
What is the behavior of a non-competitive antagonist?
Emax is lowered, no matter the concentration of the agonist
What are the competitive, reversible alpha antagonists?
Phentolamine + Prazosin
What is the irreversible, non-competitive alpha antagonists?
What are the six major things that occur with alpha blockade?
Decreased resistance to urinary flow
Inhibition of ejaculation
What occurs once vasoconstriction is reversed with an alpha blocker?
Baroreceptors sense decrease in BP and increase SNS output
Why does reflex tachycardia occur with an alpha blocker?
Stimulates baroreceptors = increase NE release
NE --> Beta = Increased HR
What happens when you block the alpha effects of epinephrine?
Drop in BP due to lack of vasocontriction
Heart rate increase