Lecture 16 - Adrenergic blocking agents Flashcards Preview

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Flashcards in Lecture 16 - Adrenergic blocking agents Deck (65)
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1

What are the alpha-receptor blockers? (two)

Phentolamine
Phenoxybenzamine

2

What are the Alpha1 blockers? (one)

Prazosin

3

What is the alpha2 blocker?

Yohimbine

4

What are the beta blockers? (three)

Propranolol
Timolol
Sotalol

5

What are the beta1 blockers?

Metoprolol
Atenolol

6

What is the general distribution of alpha receptors?

Blood vessels

7

What does alpha 1 cause?

Mydriasis
Vasoconstriction
Contraction of genitourinary muscle
Ejaculation

8

What does alpha2 cause?

decrease NE release
Suppress insulin secretion

9

What does alpha blockade do you cardiovascular system?

Decrease peripheral resistance = Decrease D pressure
= decrease BP
Decrease venous return = othrostatic hypotension

10

What does alpha blockade do to the eyes?

Miosis (via lack of radial muscle stimulation)

11

What happens to the nasal passages with alpha blockade?

Nasal congestion due to decreased vasoconstriction

12

What happens to urinary flow with alpha blockade?

urine flow increases
Base of bladder + urinary sphincter + prostate relax

13

What happens to sexual reproduction with alpha blockade?

Ejaculation inhibited

14

What do alpha2 blocking agents do?

Increase NE release

15

What is the basic distribution of beta receptors?

Heart

16

What does the B1 receptor do? (two things)

Increase heart rate and force
Increase renin secretion

17

What does B2 stimulation cause? (four things)

Relax bronchioles
Dilate BV supplying skeletal muscles
Increase glycogenolysis
Increase aqueous humor + intraocular pressure

18

What does B2 stimulation cause?

Lipolysis

19

What are the basic three things that occur with beta blockade in the heart and kidney ?

Decrease in HR and force
Decrease in CO and O2 demand
Decrease in renin secretion

20

What will happen overtime with beta blockade?

Decrease in BP in patients with hypertension

21

What does beta blockade cause with metabolism?

Decrease glycogenolysis + lipolysis

22

What is the behavior of a competitive antagonist?

If enough agonist is present can reach Emax

23

What is the behavior of a non-competitive antagonist?

Emax is lowered, no matter the concentration of the agonist

24

What are the competitive, reversible alpha antagonists?

Phentolamine + Prazosin

25

What is the irreversible, non-competitive alpha antagonists?

Phenyoxybenzamine

26

What are the six major things that occur with alpha blockade?

Reduced vasoconstriction
Reflex tachycardia
Miosis
Nasal stuffiness
Decreased resistance to urinary flow
Inhibition of ejaculation

27

What occurs once vasoconstriction is reversed with an alpha blocker?

Baroreceptors sense decrease in BP and increase SNS output

28

Why does reflex tachycardia occur with an alpha blocker?

Decreased BP
Stimulates baroreceptors = increase NE release
NE --> Beta = Increased HR

29

What happens when you block the alpha effects of epinephrine?

Drop in BP due to lack of vasocontriction
Heart rate increase

30

What receptors does phentolamine target?

Alphas