Flashcards in Lecture 11/12 - Cholinergic Agonists Deck (79)
What are the direct acting cholinergic agonists? (six)
What are the cholinesterase inhibitors? (six)
What abnormality inhibits ACh release?
What can prolong the effects of ACh?
What does ACh stimulate?
M + N
Where are muscarinic receptors located?
PNS effector organs
What is M1+3 linked to?
What is M2 linked to?
Where are muscarinic receptors where the PNS is not?
What do nicotinic receptors respond to?
ACh + Nicotine
What is a special characteristic of nicotinic recptors?
Where are nicotinic receptors found?
Why can drugs select between NMJ and autonomic nicotinic receptors?
Both have different structures
What is direct action?
Agonist binds and stimulates receptor
What is indirect action?
Molecule binds to enzyme or other part of pathway that leads to a different effect of NT
What will happen with ACh injection/
Slowing of HR - M2
Drop in BP - M3
Why can't you give ACh orally?
Charged, not absorbed
What does bethanechol stimulate?
M receptors only
What effects predominate with bethanechol?
Bladder + GI
Does bethanechol enter the brain? Why?
What does pilocarpine stimulate?
M receptors only
What are the distribution characteristics of pilocarpine?
Not charged, so taken orally
Gets into CNS
What is pilocarpine used for in the eye?
Decrease intraocular pressure (M3)
What is really sensitive to pilocarpine that leads to side effects? what are the effects?
Sweat + Salivary glands
What does muscarinic stimulation do to the heart?
Vagal stimulation = Bradycardia (M2)
Conduction slowed through AV node
Pre-synaptic decrease NE = Decrease HR (M2)
What does muscarinic stimulation do to the blood vessels?
NO PNS, but M3 is present on endothelium
ACh given IV will cause vasodilation
How does ACh given IV cause vasodilation?
What happens with release of NO from endothelial cells?
cGMP production + Vasodilation
What is the PNS tone like in the GI tract?
High, responsible for digestion