Lecture 11/12 - Cholinergic Agonists Flashcards Preview

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Flashcards in Lecture 11/12 - Cholinergic Agonists Deck (79)
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1

What are the direct acting cholinergic agonists? (six)

ACh
Muscarine
Nicotine
Carbachol
Bethanechol
Pilocarpine

2

What are the cholinesterase inhibitors? (six)

Edrophonium
Neostigmine
Pyridostigmine
Physostigmine
Organophosphates
Pralidoxime

3

What abnormality inhibits ACh release?

Botulism

4

What can prolong the effects of ACh?

AChE inhibitors

5

What does ACh stimulate?

M + N

6

Where are muscarinic receptors located?

PNS effector organs

7

What is M1+3 linked to?

Gq

8

What is M2 linked to?

Gi

9

Where are muscarinic receptors where the PNS is not?

Sweat glands

10

What do nicotinic receptors respond to?

ACh + Nicotine

11

What is a special characteristic of nicotinic recptors?

Rapid desensitization

12

Where are nicotinic receptors found?

Brain
Adrenal medulla
Autonomic ganglia
NMJ

13

Why can drugs select between NMJ and autonomic nicotinic receptors?

Both have different structures

14

What is direct action?

Agonist binds and stimulates receptor

15

What is indirect action?

Molecule binds to enzyme or other part of pathway that leads to a different effect of NT

16

What will happen with ACh injection/

Slowing of HR - M2
Drop in BP - M3

17

Why can't you give ACh orally?

Charged, not absorbed

18

What does bethanechol stimulate?

M receptors only

19

What effects predominate with bethanechol?

Bladder + GI

20

Does bethanechol enter the brain? Why?

No, charged

21

What does pilocarpine stimulate?

M receptors only

22

What are the distribution characteristics of pilocarpine?

Not charged, so taken orally
Gets into CNS

23

What is pilocarpine used for in the eye?

Decrease intraocular pressure (M3)

24

What is really sensitive to pilocarpine that leads to side effects? what are the effects?

Sweat + Salivary glands
Drooling

25

What does muscarinic stimulation do to the heart?

Vagal stimulation = Bradycardia (M2)
Atrial-muscarinic receptors
Conduction slowed through AV node
Pre-synaptic decrease NE = Decrease HR (M2)

26

What does muscarinic stimulation do to the blood vessels?

NO PNS, but M3 is present on endothelium
ACh given IV will cause vasodilation

27

How does ACh given IV cause vasodilation?

NO

28

What happens with release of NO from endothelial cells?

cGMP production + Vasodilation

29

What is the PNS tone like in the GI tract?

High, responsible for digestion

30

What are the effects of muscarine on the GI tract?

Motility + Peristalsis increase
Tone increases
Salivary + Gastric secretions increase
Sphincters relax