Lecture 4/5 - Pharmacodynamics Flashcards Preview

Pharmacology I > Lecture 4/5 - Pharmacodynamics > Flashcards

Flashcards in Lecture 4/5 - Pharmacodynamics Deck (65)
Loading flashcards...
1

What is different about how corticosteroids interact with the cell?

Act on nuclear receptors, altering genes expressed. this causes its effects to be expressed for several weeks even with the drugs gone

2

What is an electrostatic interaction?

Attraction between functional groups w/ opposite charges
Can be either strong or weak depending on the charge strength

3

Describe hydrogen bonds.

Hydrogen covalently bonded to an electronegative atom
Weak

4

What tends to act on intracellular receptors?

Hormone/drug crosses plasma membrane

5

What is commonly the effect of intracellular receptor activation?

As a complex, stimulates gene transcription OR removes an inhibtion

6

What is the typical characteristics of intracellular receptor reaction time?

Normally has a lag period but will persist over time

7

What five examples given in lecture activate intracellular receptors?

Corticosteriods
Mineralcorticoids
Sex steroids
Vitamin D
Thyroid hormone

8

What is the structure of a transmembrane protein?

Polypeptides w/ extracellular hormone binding domain + cytoplasmic enzyme domain

9

What are the three kinds of enzymes involved with the transmembrane proteins?

Tyrosine kinase + Serine kinase + Guanylyl cyclase

10

What happens to the transmembrane protein receptors once stimulated?

They are down regulated

11

What are three examples given in lecture of protein tyrosine kinase receptors?

Insulin + Epidermal GF + PDGF

12

Describe ligand-gated channels.

Receptor is linked to an ion channel, when ligand binds channel is opened and ions rush in or out of the cell

13

What ion is paired with acetylcholine/nicotinic receptors?

Na

14

What ion is paired with GABA receptors?

Cl-

15

What ion is paired with benzodiazepine receptors?

Cl

16

What ion is paired with the glutamate receptor?

Ca or Na

17

Describe a G-protein coupled receptor.

Coupled with G-protein to intracellular second messengers, spans the whole membrane

18

What do G proteins interact with?

GTP, stimulate binding + hydrolysis = GDP

19

What do Gs receptors do?

Stimulation the formation of cAMP

20

What do Gi receptors do?

Inhibit the formation of cAMP

21

What does cAMP do if it is activated?

PDE breaks down cAMP
cAMP also binds to intracellular protein kinases = phosphorylation of PKA + CREB

22

What is a major Gs receptor?

Beta1

23

What is a major Gi receptor?

Alpha 2

24

What compounds stimulate Gs?

EPI - NE - Isoproterenol - Dobutamine - Histamine - FSH - ACTH

25

What compounds stimulate Gi?

NE - EPI - Dexmedetomidine - Acetylcholine - Morphine - Serotonin

26

What does Gq activate?

Phospholipase C

27

What does PLC do?

Hyrolyze PIP2 into
IP3
DAG

28

What does IP3 do?

release calcium stores

29

What does DAG do?

Stimulate PKC

30

What compounds stimulate Gq?

Acetylcholine - NE/EPI - Phenylephrine - Serotonin