Pathoma: Disorders of Pigmentation and Melanocytes Flashcards
Melanin is made from _________.
tyrosine
Melanosomes are passed off to ________.
keratinocytes
Melanocytes are derived from the _________.
neural crest
Vitiligo can be associated with ________.
other autoimmune disorders
Freckles are characterized by increased _______, not melanocytes.
melanosomes
What is a melasma?
It is a mask-like pigmentation of the cheeks in conjunction with pregnancy or oral contraceptive use.
Melanoma will not have ___________.
hairs; only nevi do
Nevi start as __________, but usually progress to ________.
junctional; intradermal (so most adult moles will be intradermal)
Dysplastic nevus syndrome is an ___________.
autosomal dominant disorder that can lead to melanoma (because the melanocytes are dysplastic)
Radial-phase melanomas are not ____________.
as risky as depth phase for metastasis
Lentiginous melanoma has a ________ prognosis.
good (because they grow like a lens on the stratum basalis)
Nodular melanomas have a __________ prognosis.
poor (because they quickly grow down)
The only form of melanoma not related to UV light is __________.
acral melanoma (also more common in darker individuals)
