Pathoma: Secondary Hemostasis

Question 1

The clinical features of secondary hemostasis disorders are __________.

Answer 1

bleeding into joints, bleeding into muscles, and re-bleeding after surgery

Question 2

Describe the inheritance of hemophilia A.

Answer 2

X-linked recessive deficiency of factor VIII; frequent de novo mutation

Question 3

Those with factor VIII inhibitors have _________.

Answer 3

abnormal one-one mixing results

Question 4

Genetically, the most common type of vWD is __________.

Answer 4

autosomal dominant

Question 5

How do you treat von Willebrand type I?

Answer 5

Give desmopressin, which induces release of vWF from Weibel-Palade bodies

Question 6

Which enzyme does Coumadin block?

Answer 6

Epoxide reductase, which is necessary for activation of vitamin K

Question 7

What are the three main reasons patient develop deficiency of vitamin K?

Answer 7

Being a newborn; prolonged antibiotic therapy; and malabsorption

Question 8

Liver failure leads to ______________.

Answer 8

failure to produce coagulation factors and absence of epoxide reductase, which is normally present in the liver