Pathoma: Thrombosis

Question 1

Postmortem clots are distinguished from premortem clots becayse premortem clots __________.

Answer 1

are attached to the vessel wall and have lines of Zahn (alternating lines of RBCs and fibrin)

Question 2

What factors can cause stasis?

Answer 2

Immobility, cardiac wall dysfunction (atrial fibrillation), and aneurysm

Question 3

Where is t-PA made?

Answer 3

The endothelium

Question 4

What are three causes of endothelial damage?

Answer 4

High levels of serum homocysteine (due to vitamin B12 deficiency, athersclerosis, and vasculitis

Question 5

Homocysteine gets converted to __________; defect of the enzyme that does so (called __________) results in thrombosis, mental retardation, lens dislocation, and long, slender fingers.

Answer 5

cystathionine; cystathionine beta synthase

Question 6

Protein C and S deficiencies have increased risk of (besides thrombosis) ________.

Answer 6

warfarin-induced skin necrosis, because they have less protein C and S to begin with (amplifying the temporary hypercoagulable state)

Question 7

In antithrombin deficiency, the _____ does not rise in response to heparin.

Answer 7

PTT