Pathoma: Lymphoma and Hodgkin's

Question 1

LAD is __________.

Answer 1

lymphadenopathy

Question 2

Painful LAD is usually _______, while painless LAD can be _________.

Answer 2

acute infection; due to chronic inflammation (such as RA), HIV, or malignancy (metastatic or due to lymphoma)

Question 3

Which region of the lymph node would be expanded for a lymph node draining a cancer?

Answer 3

The medulla

Question 4

Which is more common, NHL or HL?

Answer 4

NHL (60% of lymphomas)

Question 5

Describe the presentation of follicular lymphoma.

Answer 5

Proliferation of neoplastic, CD20+ B cells in the follicle; common in late adolescence/early adulthood; painless LAD; t(14:18) BCL2/IgH

Question 6

What does rituximab target?

Answer 6

CD20 (hence great for B cell neoplasms)

Question 7

How can infectious hyperplasia of the lymph nodes be distinguished from follicular lymphoma?

Answer 7

Benign hyperplasia of the lymph nodes will have tingible body macrophages, there to eat negatively selected B cells

Question 8

Describe the presentation of mantle cell lymphoma.

Answer 8

Painless LAD; neoplastic expansion of the region adjacent to the follicle; t(11;14) cyclin D fusion expansion;

Question 9

Cyclin D causes the cell to go from the ______.

Answer 9

G1 to the S phase

Question 10

Marginal zone lymphoma presents with ___________.

Answer 10

neoplastic expansion of the margin; associated with chronic inflammatory states

Question 11

MALTomas are seen in those with ________.

Answer 11

H. pylori gastritis (think, chronic inflammation)

Question 12

Which types of NHL are associated with disintegration of the lymph node structure?

Answer 12

Burkitt lymphoma and DLBCL

Question 13

Burkitt lymphoma is associated with _________.

Answer 13

c-myc translocation t(8;14); Africans have jaw kind, and the sporadic kind is more abdominal; starry-sky sign

Question 14

What are the small, intermediate, and large kinds of NHL?

Answer 14

Small = follicular, mantle, and marginal; intermediate = Burkitt; large = diffuse large B cell lymphoma

Question 15

Follicular lymphoma sometimes develops into _______.

Answer 15

diffuse large B cell lymphoma

Question 16

List some descriptions of Reed-Sternberg cells.

Answer 16

They have CD30 and CD15; large with multi-lobed nuclei; secrete cytokines to form masses in lymph nodes

Question 17

Fibrotic masses in lymph nodes would be ______.

Answer 17

NHL (most often nodular sclerosis)