Sketchy Pharm: Prostaglandins, Prostacyclins, Bosentan, and PDE5 Inhibitors

Question 1

What prostaglandin drug is used to treat erectile dysfunction?

Answer 1

Alprostadil (the erect dill pickle); this agent is a PGE1 analog (the skateboarder with the dill pickle skateboard loves EEExtreme sports); this works by dilating vasodilating arteries –can also be used to keep PDAs open (the bat he’s skating with is hitting the PDA pipe open)

Question 2

Misoprostol is what kind of drug?

Answer 2

A PGE1 analog –think of the kid MISsing the ball with the bat in the Extreme sports section

Question 3

What is misoprostol used for?

Answer 3

It stimulates protective mucus secretion in the GI tract and can be used to combat NSAID-related GI symptoms. Also, it can stimulate uterine contraction to promote labor or terminate pregnancy (the misoprostol boy knocked over the stack of uterus-shaped backpacks, spilling their contents).

Question 4

Dinoprostone is what prostaglandin analog?

Answer 4

PGE2 (T-rex has Two arms)

Question 5

What is dinoprostone used for?

Answer 5

To stimulate cervical dilation and uterine contraction –facilitating labor or abortion (kid with the dino helmet spilling the uterus backpack).

Question 6

Carboprost mimics what molecule?

Answer 6

PGF-2alpha (the kid in the Footwear section with the CARdBOard box on his head)

Question 7

Carboprost stimulates what?

Answer 7

Uterine contraction –useful in stimulating labor or preventing hemorrhage

Question 8

Name two other PGF-2alpha drugs.

Answer 8

Latanoprost and travoprost (LA TAN sandals and TRAVel boots in the Footwear section)

Question 9

Latanoprost and travoprost are used mainly for _____________.

Answer 9

glaucoma treatment (they increase aqueous humor outflow – not production! – as indicated by the eyeglass cleaner flowing over in excess from the overexcited kid)

Question 10

Prostacyclins are mainly used to treat ____________.

Answer 10

pulmonary hypertension (the girl wielding fibrosed lung rackets in front of the PRO-CYCLer ball machine)

Question 11

Why are prostacyclins used to pulmonary hypertension?

Answer 11

Because they are potent vasodilators (the dilated ball shooter)

Question 12

What are two prostacyclin drugs commonly used to treat pulmonary hypertension?

Answer 12

Iloprost and epoprostenol

Question 13

Prostacyclins must be given _____________.

Answer 13

intravenously

Question 14

PDE5 inhibitors prevent the breakdown of ___________.

Answer 14

cGMP (the GruMP beneath the “don’t PHOSTEr DISinterest in sports)

Question 15

PDE5 inhibitors end in _________.

Answer 15

-fill (such as sildenafil and tadanafil

Question 16

Sildenafil and tadanafil are used to treat ____________.

Answer 16

pulmonary hypertension and erectile dysfunction (the rackets –again –and Babe Ruth’s erect bat)

Question 17

The pulmonary hypertension drug that requires monthly liver tests due to hepatotoxicity has what mechanism?

Answer 17

Endothelin inhibition (inducing vasodilation); this is bosentan (BOSs maN sTAN)