Pathoma: Wound Healing Flashcards
The labile tissues include __________.
skin, GI lining, and bone marrow
______ is a marker of hematopoietic stem cells.
CD34
The stem cells of the lungs are _________.
type II pneumocytes
What are quiescent tissues?
Those that can regenerate when needed, such as hepatocytes or proximal renal tubule
The three tissues that lack regenerative potential are __________.
neurons, skeletal muscles, and myocardium
If skin is labile and can be replaced, then why do we still develop scars on our skin?
We develop permanent scars on the skin only when the basal layer has been damaged (i.e., when the stem cells have been removed).
There are three key tissues in wound repair: ____________.
fibroblasts (which deposit type III collagen), capillaries (which provide nutrients), and myofibroblasts (which contract the wound)
What cell type is key in granulomas?
Epitheliod histiocytes, a type of macrophage
In scars, what types of collagen occur?
Type III is replaced by I
The most pliable collagen is ________.
type III
_______ is a cofactor for collagenase.
Zinc
What does platelet-derived growth factor do?
It promotes endothelial growth, fibroblast growth, and smooth muscle growth.
It’s kind of counter-intuitive, but what does fibroblast growth factor do?
It promotes angiogenesis.
There are two kinds of wound healing: _________.
primary intention, in which damaged tissues are brought together, and secondary intention, in which granulation tissue must fill in between damaged tissues.
Myofibroblasts ____________.
help contract granulation tissue
