perinatal infection- group B beta-hemolytic streptococci

Question 1

GBS pathogenesis

Answer 1

GBS is commonly found in
normal GI tract flora
(30% of women have
asymptomatic vaginal
colonization with GBS )
transmitted vertically (mother to fetus )
during labor (direct contact)

Question 2

GBS in neonates

Answer 2

*1 in 500 neonates will develop serious clinical infections or sepsis:
Early onset and Late-onset

Question 3

• Early (GBS)onset infection

Answer 3

n is the most common finding, occurring within a
few hours
to days of birth, and is characterized by fulminant pneumonia and
sepsis.

Question 4

Late-onset (GBS) infection

Answer 4

is less common, occurring after the first week of
life, and is characterized by meningitis. This is usually hospital acquired

Question 5

Intrapartum antibiotic prophylaxis of neonatal GBS sepsis is

Answer 5

IV penicillin G.
**If the patient is penicillin-allergic, use clindamycin or vancomycin

Question 6

Candidates for antibiotic prophylaxis are selected as follow

Answer 6

• women with a positive GBS urine culture
• Has aprevious baby with GBS sepsis
• Positive GBS in vaginal and rectal cultures are obtained at 36 -37 weeks
• preterm gestation (<37 weeks)
• membranes ruptured >18 h
• maternal fever (≥100.4°F) (38°C)