STD- granuloma inguinale(donovanosis)

Question 1

Granuloma Inguinale pathogenesis :

Answer 1

*This disease is caused by Calymmatobacterium granulomatis, a gram-negative intracellular bacterium.
*A vulvar nodule breaks down, forming a painless, beefy red, highly vascular ulcer with fresh granulation tissue without
regional lymphadenopathy.
*Lymphatic obstruction can result in marked vulvar enlargement. (Chronic scarring can lead to lymphatic obstruction.)

Question 2

Granuloma Inguinale Diagnosis:

Answer 2

Culture of the organism is difficult, but microscopic examination of an ulcer smear will reveal Donovan bodies.

Question 3

Granuloma Inguinale Management:

Answer 3

Oral doxycycline or azithromycin for three weeks