perinatal infections-CMV

Question 1

Methods of diagnosing CMV infection step by step

Answer 1

1) IGg titer ,pcr or viral culture
2) targeted sonography
3) Amniocentesis after 21 weeks gestation ( according to ultrasound findings)
4) 2 samples of CMV IgG serology ,3-4 weeks apart
**if from negative to positive or increasing titres in samples=primary CMV
or low avidity=primary infection
5) CMV IgG avidity is used when both IgM and IgG are positive.
** Low avidity indicates an infection that occurred in the last 6 months while high
avidity rules out the possibility that infection occurred in the last 4 months

Question 2

fetal ultrasound findings in congenital cytomegalo virus

Answer 2

*periventricular calcification
*ventriculomegaly
*microcephaly
*intrahepatic calcifications
*fetal growth restrictions (IUGR)
*hydrops fetalis

Question 3

neonatal features of congenital cytomegalovirus

Answer 3

*petechiae (from thrombocytopenia)
*hepatosplenomegaly
*chorioretinitis
*microcephaly

Question 4

long term sequelae of CCMV

Answer 4

*sensorineural hearing loss
*seizures
*developmental delay

Question 5

most common cause of sensorineural hearing loss in children

Answer 5

CMV